Clostridium perfringens toxin genotypes in the feces of healthy North Americans
Clostridium perfringens toxin genotypes in the feces of healthy North Americans
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DOI：
10.1016/j.anaerobe.2008.01.003
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发表时间：
2008-04-01
期刊：
影响因子：
2.3
通讯作者：
McClane, Bruce A.
中科院分区：
文献类型：
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作者：
Carman, Robert J.;Sayeed, Sameera;McClane, Bruce A.
我们调查了产气荚膜梭菌在健康北美人正常粪便植物群中的频率。43名受试者中约有一半被产气荚膜梭菌定殖，其水平类似于10（6）cfu/g粪便。仅回收到A型菌株。孢子的数量有时超过营养细胞。结果表明，供者有多种基因型，有的供者有两种基因型，有的供者只有一种基因型。我们在所有捐献者的粪便中没有发现α，β 2或肠毒素。虽然一些分离株携带质粒上的毒素基因（如cpe和cpb 2），但我们没有看到任何迹象表明健康人是产气荚膜梭菌食物中毒病例中染色体传播的cpe的宿主。(c)2008爱思唯尔有限公司保留所有权利。
We investigated the frequency of Clostridium perfringens in the normal fecal flora of healthy North Americans. About half of 43 subjects were colonized with C perfringens at levels of similar to 10(6) cfu/g feces. Only type A strains were recovered. Spores sometimes outnumbered vegetative cells. Several genotypes were found. Some donors carried two genotypes, some only one. We found no alpha, beta2 or enterotoxin in the stools of any donors. Though some isolates carried toxin genes (e.g. cpe and cpb2) on plasmids, we saw no indication that healthy humans are the reservoir for the chromosomally-borne cpe recovered from cases of C perfringens food poisoning. (c) 2008 Elsevier Ltd. All rights reserved.