DEVELOPMENT OF BEHAVIORAL FUNCTION OF CEREBELLAR HYPOPLASIA RATS AS INDUCED BY CYTOSINE-ARABINOSIDE (ARA-C)
DEVELOPMENT OF BEHAVIORAL FUNCTION OF CEREBELLAR HYPOPLASIA RATS AS INDUCED BY CYTOSINE-ARABINOSIDE (ARA-C)
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DOI：
10.1254/fpj.76.33
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发表时间：
1980-01-01
影响因子：
--
通讯作者：
CHIBA, T
中科院分区：
文献类型：
--
作者：
OGURA, H;MIKAMI, T;CHIBA, T
小鼠出生后第2 ~ 4天，以12.5和25 mg/kg / d的剂量给药阿糖胞苷（ara-C）。体重和生存能力受到剂量依赖性抑制。高剂量组和21日龄组的听惊反应出现延迟，其移动行为与老年大鼠相似。治疗组未出现自由落体翻正反射。野外试验显示，只有接受过治疗的雌鼠表现出低活动性。治疗组在旋转棒运动中表现出较差的神经肌肉能力，在攀竿运动中表现出条件回避反应和非条件回避反应的障碍。组织病理学和生化研究显示小脑发育不全。这些发现提示由ara- c诱导的小脑疾病引起的行为功能障碍。
Cytosine arabinoside (ara-C), an antiproliferative agent, was given s.c. to Sprague-Dawley rats on the 2nd-4th postnatal day in doses of 12.5 and 25 mg/kg per day. Body weight and viability were dose-dependently inhibited. The appearance of audio-startle response was delayed in the group on the high dose and up to 21 days of age, the ambulatory behavior resembled that seen in geriatric rats. The free-fall righting reflex failed to appear in the treated groups. The open field test revealed that only the treated females were hypoactive. The treated group showed a poor neuro-muscular ability in the rotarod performance and impairment of acquiring conditioned and unconditioned avoidance response in pole climbing. Histopathological and biochemical studies revealed a hypoplasia of the cerebellum. These findings are suggestive of behavioral dysfunction caused by ara-C-induced cerebellar disorders.