BRONCHIAL HYPERRESPONSIVENESS TO METHACHOLINE IN PATIENTS WITH PRIMARY SJOGRENS-SYNDROME
BRONCHIAL HYPERRESPONSIVENESS TO METHACHOLINE IN PATIENTS WITH PRIMARY SJOGRENS-SYNDROME
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DOI：
10.1136/ard.50.1.36
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发表时间：
1991-01-01
影响因子：
27.4
通讯作者：
HALLGREN, R
中科院分区：
文献类型：
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作者：
GUDBJORNSSON, B;HEDENSTROM, H;HALLGREN, R
前瞻性研究了21例原发性干燥综合征患者吸入甲胆碱后支气管高反应性（BHR）的发生率。12/20（60%）的患者出现轻度至重度BHR。12例BHR患者中有10例（83%）有非生产性咳嗽、喘息或间歇性呼吸困难。支气管高反应性在有腺外症状的患者中更常见（10/14,71%），而在只有腺外症状的患者中更常见（29%）。肺活量测定显示29%（6/21）的患者为“小气道疾病”，所有患者均为BHR。在6/21（29%）的弥漫性间质性肺疾病患者中，2例有BHR。4例阻塞性肺功能患者中3例使用甲胆碱治疗，2例出现BHR。只有2例BHR患者肺量测量结果正常。数据显示，呼吸系统疾病——大多是轻度或中度，但甚至是严重的支气管高反应性——常见于原发性乔根综合征患者。
The prevalence of bronchial hyperresponsiveness (BHR) to methacholine inhalation in a consecutive series of 21 patients with primary Sjogren's syndrome was studied prospectively. Slight to severe BHR was seen in 12/20 (60%) of the patients. Ten of 12 patients with BHR (83%) had a non-productive cough, wheezing, or intermittent breathlessness. Bronchial hyperresponsiveness was more common in patients with extraglandular symptoms (10/14, 71%) than in those with only glandular symptoms (29%). Spirometrically 29% (6/21) of the patients had 'small airways' disease', and all those had BHR. Of 6/21 (29%) who had diffuse interstitial lung disease, two had BHR. Three of the four patients with obstructive lung function were challenged with methacholine and two of them had BHR. Only two patients with BHR had normal spirometry findings. The data showed that respiratory disease-mostly mild or moderate but even severe bronchial hyperresponsiveness-is commonly seen in patients with primary Sjorgen's syndrome.