Gallium (III) Complexes in Cancer Chemotherapy
Gallium (III) Complexes in Cancer Chemotherapy
复制标题
镓 (III) 配合物在癌症化疗中的应用
DOI：
10.1002/ejic.202100953
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发表时间：
2021
影响因子：
2.3
通讯作者：
Jun‐Long Zhang
中科院分区：
文献类型：
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作者：
X. Peng;Songsong Gao;Jun‐Long Zhang
自上世纪以来，第 13 族金属镓就被发现具有抗癌的潜力。三价Ga(III)与Fe(III)除了氧化还原活性外大部分化学性质相同，因此在体外和体内均可作为Fe(III)的竞争性抑制剂，从而有助于其抗肿瘤活性。作为 Fe(III) 模拟物，Ga(III) 可以通过转铁蛋白摄取到细胞中并储存在铁蛋白中。此外，它还破坏铁依赖性过程，例如，通过抑制呼吸链中核糖核苷酸还原酶和含铁蛋白质的活性。为了解决循环系统中复杂的Ga(III)形态问题，大量的配体被用来形成Ga(III)络合物，提供多种功能。在这篇综述中，我们总结了Ga(III)的抗癌机制，并介绍了许多具有巨大抗肿瘤潜力的Ga(III)配合物。
Gallium, the group 13 metal, has been found to be potentially useful in fighting against cancers since last century. The trivalent Ga(III) shares most chemical properties except redox activity with Fe(III), so that it acts as a competitive inhibitor of Fe(III) in vitro and in vivo, which contributes to its antineoplastic activity. As an Fe(III) mimic, Ga(III) can be uptaken into cells through transferrin and be stored in ferritin. Furthermore, it disrupts Fe‐dependent processes, for example, by inhibiting the activity of ribonucleotide reductase and Fe‐containing proteins in the respiratory chain. To solve the problems of complex Ga(III) speciation in the circulatory system, a large number of ligands were applied to form Ga(III) complexes, supplying multiple functions. In this review, we summarized the anticancer mechanisms of Ga(III) and introduce numerous Ga(III) complexes with great antineoplastic potential.