Prediction of joint algal toxicity of nano-CeO2/nano-TiO2 and florfenicol: Independent action surpasses concentration addition.
Prediction of joint algal toxicity of nano-CeO2/nano-TiO2 and florfenicol: Independent action surpasses concentration addition.
复制标题
DOI：
10.1016/j.chemosphere.2016.04.072
复制
发表时间：
2016-08
期刊：
影响因子：
8.8
通讯作者：
Zhuang Wang;Se Wang;W. Peijnenburg
中科院分区：
文献类型：
--
作者：
Zhuang Wang;Se Wang;W. Peijnenburg
水生生物很可能在环境中同时接触工程纳米粒子（ENP）和抗生素。然而，共同暴露对水生生物的影响实际上尚不清楚，了解 ENP 和抗生素的联合毒性是一个重要的话题。独立作用（IA）模型和浓度添加（CA）模型是混合物毒性评估的两种最常见的方法。本研究确定了两种 ENP（nCeO2 和 nTiO2）和一种抗生素（氟苯尼考，FLO）对蛋白核小球藻的联合毒性，以比较 IA 和 CA 模型的适用性。对单一毒物和含有 FLO 和一种 ENP 的两种悬浮颗粒浓度的二元混合物进行了浓度响应分析。将二元混合物的效应浓度和观察到的效应与联合毒性的预测进行比较。观察到的与 nCeO2 或 nTiO2 暴露相关的毒性因伴随的 FLO 暴露而增强。 nCeO2和FLO的联合毒性显着高于nTiO2和FLO。基于 IA 和 CA 模型的预测往往会低估二元混合物的总体毒性（就中值效应浓度而言），但无论考虑的效应水平和研究的混合物类型如何，IA 的表现都优于 CA。这一结果表明需要考虑 ENP 和有机化学品的混合物对水生生物的影响，以及 IA 和 CA 方法在 ENP 毒性评估中的实用性。
Co-exposure of aquatic organisms to engineered nanoparticles (ENPs) and antibiotics is likely to take place in the environment. However, the impacts of co-exposure on aquatic organisms are virtually unknown and understanding the joint toxicity of ENPs and antibiotics is a topic of importance. The independent action (IA) model and the concentration addition (CA) model are two of the most common approaches to mixture toxicity assessment. In this study, the joint toxicity of two ENPs (nCeO2and nTiO2) and one antibiotic (florfenicol, FLO) toChlorella pyrenoidosawas determined to compare the applicability of the IA and the CA model. Concentration-response analyses were performed for single toxicants and for binary mixtures containing FLO and one of the ENPs at two suspended particle concentrations. The effect concentrations and the observed effects of the binary mixtures were compared to the predictions of the joint toxicity. The observed toxicity associated with the nCeO2or nTiO2exposure was enhanced by the concomitant FLO exposure. The joint toxicity of nCeO2and FLO was significantly higher than that of nTiO2and FLO. Predictions based on the IA and CA models tend to underestimate the overall toxicity (in terms of median effect concentration) of the binary mixtures, but IA performs better than CA, irrespective of the effect level under consideration and the types of mixtures studied. This result underpins the need to consider the effects of mixtures of ENPs and organic chemicals on aquatic organisms, and the practicability of the IA and CA methods in toxicity assessment of ENPs.