Circulating Alanine Production and Disposal in Healthy Subjects
Circulating Alanine Production and Disposal in Healthy Subjects
复制标题
健康受试者的循环丙氨酸生产和处置
DOI：
10.2337/diab.27.3.287
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发表时间：
1978
期刊：
影响因子：
7.7
通讯作者：
J. Moorhouse
中科院分区：
文献类型：
--
作者：
R. Chochinov;K. Perlman;J. Moorhouse
循环丙氨酸的生产和处置率估计在8个健康的吸收后受试者的U-14 C丙氨酸和U-14 C葡萄糖输注。平均循环丙氨酸生成率为368 ± S.E.M.。28 μmol/min· 1.82。大约50%的循环丙氨酸碳与循环乳酸迅速交换。大约30%的循环丙氨酸与蛋白质储存交换。其他处置为29 ± 2%循环葡萄糖和40 ± 4%氧化。结论：（1）循环丙氨酸和乳酸的碳部分是可自由交换的。(2)丙氨酸对丙酮酸生成的贡献的评估将取决于确定前体丙酮酸碳来源于糖酵解或蛋白质水解的程度。(3)如果丙酮酸的主要前体是糖酵解，那么葡萄糖-丙氨酸循环的主要特异性功能似乎是氨转运。
Circulating-alanine production and disposal rates were estimated in eight healthy postabsorptive subjects by means of U-14C alanine and U-14C glucose infusions. The mean circulating-alanine production rate was 368 ± S.E.M. 28 μmol/min. · 1.82. Approximately 50 per cent of circulating-alanine carbon exchanged rapidly with that of circulating lactate. Approximately 30 per cent of circulating alanine exchanged with protein stores. Other disposal was 29 ± 2 per cent to circulating glucose and 40 ± 4 per cent to oxidation. Conclusions: (1) The carbon moieties of circulating alanine and lactate are freely exchangeable. (2) Assessment of the contribution of alanine to gluconeogenesls will depend on establishing the extent to which the precursor pyruvate carbon is derived from glycolysis or from proteolysis. (3) If the principal pyruvate precursor is glycolysis, then the principal specific function of the glucose-alanine cycle appears to be ammonia transport.