Role of hematopoietic growth factors/flt3 ligand in expansion and regulation of dendritic cells
Role of hematopoietic growth factors/flt3 ligand in expansion and regulation of dendritic cells
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DOI：
10.1097/00062752-200105000-00004
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发表时间：
2001-05-01
影响因子：
3.2
通讯作者：
McKenna, HJ
中科院分区：
文献类型：
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作者：
McKenna, HJ
树突状细胞（Dendritic cells，DC）是通过向T细胞呈递抗原来启动免疫应答的造血细胞。粒细胞-巨噬细胞集落刺激因子（GM-CSF）是体外DC的主要生长因子，但最近认识到包括flt 3配体（FL）和G-CSF在内的其他因子在体内扩增各种DC亚群。DC在获得抗原后和活化静息T细胞之前经历一系列复杂的成熟和活化步骤，此外，它们必须运输到淋巴结（LN）的富含T细胞的区域以实现这一点。这些步骤中的每一个都受到严格的监管，去年在确定这些步骤中涉及的一些关键分子方面取得了进展。这一进展将进一步努力开发DC作为疫苗佐剂。(C)2001年利平科特威廉姆斯&威尔金斯。Inc.
Dendritic cells (DCs) are hematopoietic cells that initiate immune responses by presenting antigen to T cells. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a primary growth factor for DCs in vitro, but recently it was recognized that other factors including flt3 ligand (FL) and G-CSF expand various DC subsets in vivo. DCs undergo a complex series of maturation and activation steps after they acquire antigen and before they can activate resting T cells, In addition, they must traffic to T-cell-rich areas of lymph nodes (LN) to achieve this. Each of these steps is tightly regulated, and in the last year progress has been made in identifying some of the key molecules involved in each of these steps. This progress will further the efforts underway to develop DCs as vaccine adjuvants. (C) 2001 Lippincott Williams & Wilkins. Inc.