Dedicated epithelial recipient cells determine pigmentation patterns
Dedicated epithelial recipient cells determine pigmentation patterns
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DOI：
10.1016/j.cell.2007.07.024
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发表时间：
2007-09-07
期刊：
影响因子：
64.5
通讯作者：
Brissette, Janice L.
中科院分区：
文献类型：
--
作者：
Weiner, Lorin;Han, Rong;Brissette, Janice L.
哺乳动物通过专门的色素产生细胞产生外部颜色，但通过基本未知的机制将色素排列成图案。在这里，使用小鼠作为模型，我们表明，图案最终来自专门的色素接收细胞。这些色素受体是上皮细胞，其将黑色素细胞募集到皮肤中的位置并诱导黑色素的转移。我们确定Foxn 1（一种转录因子）作为这种“色素受体表型”的激活剂，Fgf 2（一种生长因子和Foxn 1靶点）作为受体释放的信号。当Foxn 1--以及由此产生的专门的顺从者--在皮肤中重新分布时，新的色素沉着模式就会形成，这表明了一种颜色进化的机制。我们的结论是，收件人提供了一个皮肤模板或蓝图，指示黑色素细胞在哪里放置色素。由于Foxn 1和Fgf 2也调节上皮细胞的生长和分化，Foxn 1通路应该作为协调细胞分裂、分化和色素沉着的纽带。
Mammals generate external coloration via dedicated pigment-producing cells but arrange pigment into patterns through mechanisms largely unknown. Here, using mice as models, we show that patterns ultimately emanate from dedicated pigment-receiving cells. These pigment recipients are epithelial cells that recruit melanocytes to their position in the skin and induce the transfer of melanin. We identify Foxn1 (a transcription factor) as an activator of this "pigment recipient phenotype" and Fgf2 (a growth factor and Foxn1 target) as a signal released by recipients. When Foxn1-and thus dedicated recipients-are redistributed in the skin, new patterns of pigmentation develop, suggesting a mechanism for the evolution of coloration. We conclude that recipients provide a cutaneous template or blueprint that instructs melanocytes where to place pigment. As Foxn1 and Fgf2 also modulate epithelial growth and differentiation, the Foxn1 pathway should serve as a nexus coordinating cell division, differentiation, and pigmentation.