EPR characteristics of free radicals in DOPA-melanin-moxifloxacin complexes at ambient level of UVA radiation
EPR characteristics of free radicals in DOPA-melanin-moxifloxacin complexes at ambient level of UVA radiation
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DOI：
10.1016/j.cplett.2013.12.011
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发表时间：
2014-01-30
影响因子：
2.8
通讯作者：
Wrzesniok, Dorota
中科院分区：
文献类型：
--
作者：
Beberok, Artur;Zdybel, Magdalena;Wrzesniok, Dorota
EPR研究指出，g值2.0038-2.0040的邻半醌自由基参与莫西沙星-黑色素复合物的形成。该过程导致未辐照复合物中自由基浓度的增加。对于药物浓度为 1 x 10(-4) M、1 x 10(-3) M 和 4 x 10(-3) M 的复合物观察到了这种效应。除了药物浓度为 1 x 10(-4) M 的复合物外，紫外线照射还导致多巴-黑色素与莫西沙星复合物中的自由基浓度降低。药物浓度为 1 x 10(-3) M 的多巴-黑色素-莫西沙星复合物中自由基浓度降低最明显。所有测试的黑色素样品均表现出 EPR 谱线均匀展宽、强偶极相互作用和缓慢的自旋晶格弛豫过程。 (C) 2013 Elsevier B.V. 保留所有权利。
EPR studies pointed out that o-semiquinone free radicals with g-values 2.0038-2.0040 take part in moxifloxacin-melanin complex formation. The process contributed to increase in free radicals concentration in nonirradiated complexes. This effect was observed for the complexes with 1 x 10(-4) M, 1 x 10(-3) M and 4 x 10(-3) M drug concentrations. UV irradiation contributed to decrease in free radicals concentration in DOPA-melanin complexes with moxifloxacin, besides the complexes with the drug concentration of 1 x 10(-4) M. The strongest decrease was observed for DOPA-melanin-moxifloxacin complexes with the drug concentration of 1 x 10(-3) M. Homogeneous broadening of EPR lines, strong dipolar interactions and slow spin-lattice relaxation processes characterized all the tested melanin samples. (C) 2013 Elsevier B.V. All rights reserved.