Filling the Gap: Relationship Between the Serotonin-Transporter-Linked Polymorphic Region and Amygdala Activation
Filling the Gap: Relationship Between the Serotonin-Transporter-Linked Polymorphic Region and Amygdala Activation
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DOI：
10.1177/0956797614548877
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发表时间：
2014-11-01
影响因子：
8.2
通讯作者：
Aleman, Andre
中科院分区：
文献类型：
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作者：
Bastiaansen, Jojanneke A.;Servaas, Michelle N.;Aleman, Andre
所谓的阿托伐他汀转运蛋白连锁多态性区域（5-HTTLPR）和杏仁核激活之间的关联形成了一个共同观点的基石，即携带这种多态性的短等位基因是情感障碍的潜在危险因素。最近一项荟萃分析的作者表明，这种关联具有统计学意义（Hedges的g = 0.35），但警告说，由于出版偏倚，估计可能会被扭曲。在这里，我们报告了120名参与者的这种关系的复制研究。在广泛使用的情绪-面孔-匹配范式中，我们没有发现5-HTTLPR变异与杏仁核激活的关联。此外，当我们进行荟萃分析时，包括未发表的研究和当前研究的数据，汇总荟萃分析效应量不再显著（g = 0.20，p = 0.06）。这些发现对先前报道的实质性影响提出了质疑，表明5-HTTLR-杏仁核的关联要么比以前认为的要小得多，要么取决于其他因素，要么不存在。
The alleged association between the serotonin-transporter-linked polymorphic region (5-HTTLPR) and amygdala activation forms a cornerstone of the common view that carrying the short allele of this polymorphism is a potential risk factor for affective disorders. The authors of a recent meta-analysis showed that this association is statistically significant (Hedges's g = 0.35) but warned that estimates might be distorted because of publication bias. Here, we report a replication study of this relationship in 120 participants. We failed to find an association of 5-HTTLPR variation with amygdala activation during a widely used emotional-face-matching paradigm. Moreover, when we conducted a meta-analysis that included unpublished studies and data from the current study, the pooled meta-analytic effect size was no longer significant (g = 0.20, p = .06). These findings cast doubt on previously reported substantial effects, suggesting that the 5-HTTLPR-amygdala association is either much smaller than previously thought, conditional on other factors, or nonexistent.