Acoustic Radiation Force Impulse (ARFI) and Transient Elastography (TE) for evaluation of liver fibrosis in HIV-HCV co-infected patients.
Acoustic Radiation Force Impulse (ARFI) and Transient Elastography (TE) for evaluation of liver fibrosis in HIV-HCV co-infected patients.
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DOI：
10.1186/1471-2334-14-405
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发表时间：
2014-07-21
影响因子：
3.7
通讯作者：
Morlat P
中科院分区：
文献类型：
--
作者：
Frulio N;Trillaud H;Perez P;Asselineau J;Vandenhende M;Hessamfar M;Bonnet F;Maire F;Delaune J;De Ledinghen V;Morlat P
瞬时弹性成像（TE）被广泛用于非侵入性评估HIV-HCV合并感染患者的肝纤维化。然而，TE不能确定肝脏形态。声辐射力脉冲（ARFI）成像是一种新的程序，使评估肝纤维化在传统的超声检查。本研究评价了TE和ARFI测量肝纤维化之间的相关性。46例HIV-HCV患者均在6个月内接受了ARFI和TE。使用先前确定的临界值，通过“等效METAVIR”评分系统对患者进行评价。通过Kappa系数估计ARFI和TE评分之间的一致性，Kappa值≥0.40、≥0.60和≥0.80分别定义为中度、良好和非常好的一致性。ARFI和TE分别在26名和31名患者中产生了F1的“等效Metavir”纤维化评分;分别在9名和7名患者中产生了F2;分别在3名和2名患者中产生了F3;分别在8名和6名患者中产生了F4。两种方法在预测总体分期[Kappa = 0.82]和F ≥3 [Kappa = 0.80]方面显示出非常好的一致性，在预测显著纤维化F ≥2 [Kappa = 0.50]方面显示出中等一致性。形态超声分析伴随ARFI检测到两个肝癌。ARFI在HIV-HCV患者肝纤维化的非侵入性评估中显示出有希望的结果，肝纤维化分期与TE相似。此外，ARFI可以在同一会话期间评估形态学和纤维化。
Transient elastography (TE) is widely used for non-invasive assessment of liver fibrosis in HIV-HCV co-infected patients. TE, however, cannot determine liver morphology. Acoustic radiation force impulse (ARFI) imaging is a novel procedure enabling assessment of liver fibrosis during a conventional ultrasonographic examination. This study evaluated the correlation between liver fibrosis measurements by TE and ARFI. Each of 46 HIV-HCV patients underwent both ARFI and TE within 6 months. Patients were evaluated by the “equivalent METAVIR” scoring system, using previously established cut-off values. Agreements between the ARFI and TE scores were estimated by Kappa coefficients, with Kappa values ≥0.40, ≥0.60, and ≥0.80 defined as moderate, good and very good agreement, respectively. ARFI and TE yielded "Equivalent Metavir" fibrosis scores of F1 in 26 and 31 patients, respectively; F2 in nine and seven, respectively; F3 in three and two, respectively; and F4 in eight and six, respectively. The two methods showed very good agreement in predicting overall stages [Kappa = 0.82] and for F ≥3 [Kappa = 0.80] and moderate agreement in predicting significant fibrosis F ≥2 [Kappa = 0.50]. Morphologic ultrasound analysis concomitant to ARFI detected two hepatocarcinomas. ARFI showed promising results in the non-invasive assessment of liver fibrosis in HIV-HCV patients, with liver fibrosis staging similar to that of TE. Moreover, ARFI can assess morphology and fibrosis during the same session.
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DOI：
10.1086/597350
发表时间：
2009-04-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Kirk GD;Astemborski J;Mehta SH;Spoler C;Fisher C;Allen D;Higgins Y;Moore RD;Afdhal N;Torbenson M;Sulkowski M;Thomas DL
通讯作者：
Thomas DL
影响因子：
13.5
作者：
Bedossa, P;Dargère, D;Paradis, V
通讯作者：
Paradis, V
DOI：
10.1111/j.1440-1746.2010.06385.x
发表时间：
2011-01-01
影响因子：
4.1
作者：
Kim, Seung Up;Jang, Hui Won;Han, Kwang-Hyub
通讯作者：
Han, Kwang-Hyub
影响因子：
24.5
作者：
Foucher, J;Chanteloup, E;de Lédinghen, V
通讯作者：
de Lédinghen, V
影响因子：
13.5
作者：
Dienstag, JL
通讯作者：
Dienstag, JL