Food supplementation among HIV-infected adults in Sub-Saharan Africa: impact on treatment adherence and weight gain
Food supplementation among HIV-infected adults in Sub-Saharan Africa: impact on treatment adherence and weight gain
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DOI：
10.1017/s0029665115000063
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发表时间：
2015-11-01
影响因子：
7
通讯作者：
Ellahi, Basma
中科院分区：
文献类型：
--
作者：
Audain, Keiron A.;Zotor, Francis B.;Ellahi, Basma
撒哈拉以南非洲的营养不良人口比例居世界之首，沿着的艾滋病毒/艾滋病感染者人数也居世界之首。因此，由于粮食高度无保障，许多艾滋病毒患者也营养不良。艾滋病毒和营养不良之间的协同作用导致治疗坚持性差和死亡率高。营养不良对免疫系统有削弱作用，因为主要营养素缺乏和活性物质（氧化应激）的过度产生，导致艾滋病毒迅速发展和艾滋病的发病。用于治疗严重急性营养不良的治疗性食物补充剂正在应用于艾滋病毒姑息治疗;然而，几乎没有生物化学数据来突出其对氧化应激和免疫恢复的影响。此外，由于大多数食品补充剂是由捐助机构进口的，因此正在努力进行地方食疗食品生产，如食品多种混合概念，以确保可持续性。本次审查的目的是突出研究，检查营养不良的艾滋病毒患者在撒哈拉以南非洲的食物补充剂的有效性;注意到用于衡量疗效的参数，以及补充剂的长期可行性。
Sub-Saharan Africa has the highest proportion of undernourished people in the world, along with the highest number of people living with HIV and AIDS. Thus, as a result of high levels of food insecurity many HIV patients are also undernourished. The synergism between HIV and undernutrition leads to poor treatment adherence and high mortality rates. Undernutrition has a debilitating effect on the immune system due to key nutrient deficiencies and the overproduction of reactive species (oxidative stress), which causes rapid HIV progression and the onset of AIDS. Therapeutic food supplementation used in the treatment of severe acute malnutrition is being applied to HIV palliative care; however, little biochemical data exist to highlight its impact on oxidative stress and immune recovery. In addition, as most food supplements are imported by donor agencies, efforts are being put into local therapeutic food production such as the Food Multi-Mix concept to ensure sustainability. The purpose of this review is to highlight studies that examine the effectiveness of food supplementation in undernourished HIV patients in Sub-Saharan Africa; noting the parameters used to measure efficacy, as well as the long-term feasibility of supplementation.