Effect of weight reduction on respiratory function and airway reactivity in obese women
Effect of weight reduction on respiratory function and airway reactivity in obese women
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DOI：
10.1378/chest.125.6.2046
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发表时间：
2004-06-01
期刊：
影响因子：
9.6
通讯作者：
Dales, RE
中科院分区：
文献类型：
--
作者：
Aaron, SD;Fergusson, D;Dales, RE
工作背景：以人群为基础的研究已经证明肥胖与女性哮喘患病率增加之间存在关联。方法：我们前瞻性研究了58名体重指数> 30 kg/m2的肥胖女性，其中24名患有哮喘，她们参加了为期6个月的强化减肥计划，以确定体重减轻是否与支气管反应性、肺功能、结果：在6个月期间，患者平均损失20公斤的空气。体重每相对减轻10%，FVC改善92 mL（p = 0.05），FEV 1改善73 mL（p = 0.04），然而，支气管反应性并未随体重减轻而显著变化（p = 0.23）。与最低四分位数体重未能显著减轻的患者相比，体重减轻> 13%的患者的FEV 1（p = 0.01）、FVC（p = 0.02）和总肺活量（p = 0.05）有所改善。两组均未发生乙酰甲胆碱反应性的任何显著变化（p = 0.57）。谁完成了6个月的减肥计划的患者经历了改善呼吸系统的健康状况，无论体重loss.Conclusion：我们的结论是，减肥可以改善肥胖妇女的肺功能，但是，改善似乎是独立的气道反应性的变化。
Background: Population-based studies have documented an association between obesity and an increased prevalence of asthma in women.Methods: We prospectively studied 58 obese women with a body mass index of > 30 kg/m(2), 24 of whom had asthma, who were enrolled in an intensive 6-month weight loss program to determine whether loss of body mass would be correlated with improvements in bronchial reactivity, lung function, and disease-specific health status.Results: Patients lost air average of 20 kg over the 6-month period. For every 10% relative loss of weight, the FVC improved by 92 mL (p = 0.05) and the FEV1 improved by 73 mL (p = 0.04), however, bronchial reactivity did not significantly change with weight loss (p = 0.23). Patients who lost > 13% of their pretreatment weight experienced improvements in FEV1 (p = 0.01), FVC (p = 0.02), and total lung capacity (p = 0.05) compared to patients in the lowest quartile who failed to lose significant amounts of weight. Neither group experienced any significant change in methacholine responsiveness (p = 0.57). Patients who completed the 6-month weight loss program experienced improvements in respiratory health status, irrespective of weight loss.Conclusion: We concluded that weight loss can improve lung function in obese women, however, the improvements appear to be independent of changes in airway reactivity.