Oncologic outcomes for patients with endometrial cancer who received minimally invasive surgery: a retrospective observational study
Oncologic outcomes for patients with endometrial cancer who received minimally invasive surgery: a retrospective observational study
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接受微创手术的子宫内膜癌患者的肿瘤学结果：一项回顾性观察研究
DOI：
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发表时间：
2020
影响因子：
3.3
通讯作者：
M. Ohmichi
中科院分区：
文献类型：
--
作者：
Tomohito Tanaka;Shoko Ueda;S. Miyamoto;S. Terada;Hiromi Konishi;Yuhei Kogata;S. Fujiwara;Yoshimichi Tanaka;Kohei Taniguchi;K. Komura;M. Ohmichi
腹腔镜子宫切除术已被用于子宫内膜癌患者的微创手术;然而，与开放手术相比，高危疾病的长期结局仍不清楚。883例接受腹腔镜或腹式子宫切除术的子宫内膜癌患者被分为三组。低风险疾病定义为IA期疾病伴1级或2级类胶质瘤。子宫局限性疾病定义为IA期疾病伴高级别肿瘤或IB期和II期疾病。晚期疾病定义为III期或IV期疾病。比较腹腔镜和开腹子宫切除术的无进展生存率（PFS）和总生存率（OS）。在478例低风险疾病患者中，包括226例腹腔镜手术患者和252例剖腹手术患者，两组的预后无显著差异（3年PFS率，97.4% vs. 97.1%，p = 0.8; 3年OS率，98.6% vs. 98.3%，p = 0.9）。在229例子宫局限性疾病患者中，包括51例腹腔镜手术患者和178例剖腹手术患者，两组的预后无显著差异（3年PFS率，90.5% vs. 85.5%，p = 0.7; 3年OS率，91.3% vs. 92.5%，p = 0.8）。在176例晚期疾病患者中，包括24例腹腔镜手术和152例开腹手术，腹腔镜子宫切除术的PFS率和OS率高于开腹子宫切除术（3年PFS率，74.5% vs. 51.5%，p = 0.01; 3年OS率，92.3% vs. 75.1%，p = 0.03）。对于晚期子宫内膜癌或局限于子宫的子宫内膜癌患者，腹腔镜手术与开腹手术相比，结局并不差。
Laparoscopic hysterectomy has been performed for patients with endometrial cancer as minimally invasive surgery; however, the long-term outcomes of high-risk disease compared to open surgery remain unclear. Eight hundred and eighty-three patients with endometrial cancer who underwent laparoscopic or abdominal hysterectomy were categorized into three groups. Low-risk disease was defined as stage IA disease with endometrioid carcinoma of grade 1 or 2. Uterine-confined disease was defined as stage IA disease with high-grade tumors or stage IB and II disease. Advanced disease was defined as stage III or IV disease. The progression-free survival (PFS) and overall survival (OS) rates were compared between laparoscopic and laparotomic hysterectomy. Among 478 patients with low-risk disease, including 226 with laparoscopy and 252 with laparotomy, the prognosis was not significantly different between the groups (3-year PFS rate, 97.4% vs. 97.1%, p = 0.8; 3-year OS rate, 98.6% vs. 98.3%, p = 0.9). Among the 229 patients with uterine-confined disease, including 51 with laparoscopy and 178 with laparotomy, the prognosis was not significantly different between the groups (3-year PFS rate, 90.5% vs. 85.5%, p = 0.7; 3-year OS rate, 91.3% vs. 92.5%, p = 0.8). Among the 176 patients with advanced disease, including 24 with laparoscopy and 152 with laparotomy, laparoscopic hysterectomy had a higher PFS rate and OS rate than laparotomic hysterectomy (3-year PFS rate, 74.5% vs. 51.5%, p = 0.01; 3-year OS rate, 92.3% vs. 75.1%, p = 0.03). Laparoscopic procedures are not associated with a poorer outcome than laparotomy in patients with advanced endometrial cancer or uterine-confined endometrial cancer.
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影响因子：
158.5
作者：
Matei, Daniela;Filiaci, Virginia;Miller, David S.
通讯作者：
Miller, David S.
影响因子：
45.3
作者：
Randall, Marcus E.;Filiaci, Virginia;Miller, David S.
通讯作者：
Miller, David S.
影响因子：
45.3
作者：
Randall, ME;Filiaci, VL;Benda, JA
通讯作者：
Benda, JA
影响因子：
4.7
作者：
Fader AN;Java J;Tenney M;Ricci S;Gunderson CC;Temkin SM;Spirtos N;Kushnir CL;Pearl ML;Zivanovic O;Tewari KS;O'Malley D;Hartenbach EM;Hamilton CA;Gould NS;Mannel RS;Rodgers W;Walker JL
通讯作者：
Walker JL
影响因子：
45.3
作者：
Walker, Joan L.;Piedmonte, Marion R.;Sharma, Sudarshan K.
通讯作者：
Sharma, Sudarshan K.