The transfer of 2,4,5,2',4',5'-hexachlorobiphenyl to fetuses and nursing offspring. I. Disposition in pregnant and lactating mice and accumulation in young.
The transfer of 2,4,5,2',4',5'-hexachlorobiphenyl to fetuses and nursing offspring. I. Disposition in pregnant and lactating mice and accumulation in young.
复制标题
2,4,5,2,4,5-六氯联苯向胎儿和哺乳后代的转移。
DOI：
10.1016/0041-008x(80)90199-4
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发表时间：
1980
影响因子：
3.8
通讯作者：
Lech,JJ
中科院分区：
文献类型：
--
作者：
Vodicnik,MJ;Lech,JJ
通过在交配前2周给雌性小鼠注射6-CB，观察妊娠和哺乳期小鼠体内2,4,5,2′，4′，5′-六氯[14C]苯基（6-CB）的分布及其向胎儿和哺乳后代的转移。与未交配的对照组相比，怀孕动物的组织中[14C]6-CB的浓度没有差异。然而，在出生当天，怀孕小鼠的肝脏、脂肪组织和肾脏6-CB含量高于同期牺牲的处女。6-CB经胎盘传代极少。哺乳期母亲在产后20天基本上消除了她们整个身体的多氯联苯负担，而6-CB则由哺乳的后代积累。在此期间，没有观察到从处女对照组中可测量的6-CB消除。因此，尽管6-CB一旦被隔离到储存库中，很少通过胎盘，但它很容易通过哺乳的乳腺转移到哺乳的后代身上。
The disposition of 2,4,5,2′,4′,5′-hexachlorobi[14C]phenyl (6-CB) in pregnant and lactating mice and its transfer to fetuses and nursing offspring were examined by administration of 6-CB to virgin female mice 2 weeks prior to mating. No differences were observed in tissue concentrations of [14C]6-CB in pregnant animals when compared to virgin controls. However, on the day of birth, liver, adipose tissue, and kidney 6-CB contents in pregnant mice were higher than those in virgins sacrificed concurrently. Transplacental passage of 6-CB was minimal. Lactating mothers eliminated essentially their entire body burden of the PCB by 20 days postpartum and 6-CB was, in turn, accumulated by nursing offspring. No measurable elimination of 6-CB was observed from virgin controls during this time. Thus, although little passage of 6-CB occurred across the placenta once it had been sequestered into storage depots, it was readily transferred to suckling offspring through the lactating mammary gland.