Sensorimotor developmental delays and lower anxiety in rats prenatally exposed to cadmium
Sensorimotor developmental delays and lower anxiety in rats prenatally exposed to cadmium
复制标题
DOI：
10.1002/jat.1102
复制
发表时间：
2006-01-01
影响因子：
3.3
通讯作者：
Reale, CA
中科院分区：
文献类型：
--
作者：
Minetti, A;Reale, CA
从妊娠第7天到第15天（器官形成期），每天皮下注射0.3或0.6 mg镉（CdCl 2）kg（-1）。一个对照组不注射，另一个接受生理盐水。对后代进行感觉运动发育的个体发育测试，并在45或90日龄时进行焦虑行为测试。对感觉运动发育的研究表明，妊娠期暴露于0.6 mg Cd kg（-1）可延迟幼鼠翻正反射和悬崖厌恶的发育。在负趋地性的发展方面，也没有观察到差异，在眼睛和耳朵张开的年龄方面也没有观察到差异。使用高架十字迷宫进行的焦虑研究表明，与其他组相比，出生前暴露于0.6 mg Cd kg（-1）的所有后代的焦虑程度较低，因为这些大鼠花费更多的时间，进入开放臂的次数更多。结果表明，在器官形成过程中暴露于低水平的镉可能会改变一些中枢神经系统功能。版权所有（c）2005年约翰威利父子有限公司。
Pregnant rats were treated with 0.3 or 0.6 mg cadmium (CdCl2) kg(-1) injected subcutaneously on a daily basis from gestational day 7 to day 15 (organogenesis period). One control group was not injected and the other received saline. Offspring were tested for ontogeny of sensorimotor development and at 45 or 90 days of age for anxiety behavior. The study of sensorimotor development showed that gestational exposure to 0.6 mg Cd kg(-1) produced a delay in the development of the righting reflex and of the cliff aversion in the pups. No differences were observed in the development of the negative geotaxis, nor in the ages of eye and ear opening. Anxiety studies using an elevated plus maze showed a lower anxiety in all the offspring prenatally exposed to 0.6 mg Cd kg(-1) as these rats spent more time and entered the open arms more times compared with those of the other groups. The results demonstrate that exposure to low levels of Cd during organogenesis may modify some central nervous system functions. Copyright (c) 2005 John Wiley & Sons, Ltd.