A comparative evaluation of oxygen mass transfer and broth viscosity using Cephalosporin-C production as a case strategy
A comparative evaluation of oxygen mass transfer and broth viscosity using Cephalosporin-C production as a case strategy
复制标题
DOI：
10.1007/s11274-004-3489-1
复制
发表时间：
2005-06-01
影响因子：
4.1
通讯作者：
Kundu, S
中科院分区：
文献类型：
--
作者：
Mishra, P;Srivastava, P;Kundu, S
采用实验室规模的内环流气升式反应器，研究了利用产黄枝顶孢霉生产次级代谢产物头孢菌素C（CPC）的工艺条件。头孢菌素C生产工艺是一种高度需氧发酵工艺。体积气液传质系数（k（L）a）和粘度（eta）进行了评估，在微生物生理学的生长和生产阶段。在气升式反应器中进行头孢菌素-C生产过程中，已尝试关联发酵液粘度η和体积氧传递系数k（L）a。还评估了生物量浓度和菌丝体形态对肉汤粘度的影响。该肉汤呈现典型的非牛顿发酵液。对稠度指数、流动度指数等流变参数进行了研究。
The production of Cephalosporin-C (CPC) a secondary metabolite, using a mold Acremonium chrysogenum was studied in a lab scale Internal loop air lift reactor. Cephalosporin-C production process is a highly aerobic fermentation process. Volumetric gas-liquid mass transfer coefficient (k(L)a) and viscosity (eta) were evaluated, during the growth and production phases of the microbial physiology. An attempt has been made to correlate the broth viscosity, eta and volumetric oxygen transfer coefficient, k(L)a during the Cephalosporin-C production in an air lift reactor. The impact of biomass concentration and mycelial morphology on broth viscosity has been also evaluated. The broth exhibits a typical non-Newtonian fermentation broth. Rheology parameters like consistency index and fluidity index are also studied.