Mediation of mouse natural cytotoxic activity by tumour necrosis factor
Mediation of mouse natural cytotoxic activity by tumour necrosis factor
复制标题
肿瘤坏死因子介导小鼠天然细胞毒活性
作者：
J. Ortaldo;L. Mason;B. Mathieson;S. Liang;D. A. Flick;R. Herberman
小鼠中天然细胞介导的细胞毒性活性与两种类型的效应细胞（自然杀伤（NK）细胞和天然细胞毒性（NC）细胞）相关，这两种细胞似乎在靶标选择性模式、细胞表面特征和对调节因子的敏感性方面有所不同1。在细胞毒性分子作用机制的研究中，很明显，WEHI-164，原型NC靶细胞，对人和小鼠重组肿瘤坏死因子（TNF）的直接裂解高度敏感。在这里，我们表明，NC，但不是NK细胞介导的正常脾细胞的活性，被废除兔抗体重组和天然TNF，分别。因此，定义为NC的细胞介导活性是由于正常脾细胞释放TNF所致，并不代表独特的天然效应机制。
Natural cell-mediated cytotoxic activity in the mouse has been associated with two types of effector cells, the natural killer (NK) cell and the natural cytotoxic (NC) cell, which seem to differ with regard to their patterns of target selectivity, cell surface characteristics and susceptibility to regulatory factors1. During studies on the mechanism of action of cytotoxic molecules, it became evident that WEHI-164, the prototype NC target cell, was highly susceptible to direct lysis by both human and mouse recombinant tumour necrosis factor (TNF). Here we show that NC, but not NK activity mediated by normal splenocytes, is abrogated by rabbit antibodies to recombinant and natural TNF, respectively. Thus, the cell-mediated activity defined as NC is due to release of TNF by normal spleen cells and does not represent a unique natural effector mechanism.
肿瘤坏死因子的细胞周期特异性作用。
影响因子：
11.2
作者：
Darzynkiewicz,Z;Williamson,B;Carswell,EA;Old,LJ
通讯作者：
Old,LJ