LPS-induced renal inflammation is prevented by (-)-epicatechin in rats.
LPS-induced renal inflammation is prevented by (-)-epicatechin in rats.
复制标题
DOI：
10.1016/j.redox.2016.12.023
复制
发表时间：
2017-04
期刊：
影响因子：
11.4
通讯作者：
Galleano, Monica
中科院分区：
文献类型：
--
作者：
Denise Prince, Paula;Fischerman, Laura;Toblli, Jorge E.;Fraga, Cesar G.;Galleano, Monica
This work investigated the capacity of (−)-epicatechin to prevent the renal damage induced by LPS administration in rats. Male Sprague Dawley rats were fed for 4 days a diet without or with supplementation with (−)-epicatechin (80 mg/kg BW/d), and subsequently i.p. injected with lipopolysaccharide (LPS). Six hours after injection, LPS-treated rats exhibited increased plasma creatinine and urea levels as indicators of impaired renal function. The renal cortex of the LPS-treated rats showed: i) increased expression of inflammatory molecules (TNF-α, iNOS and IL-6); ii) activation of several steps of NF-κB pathway; iii) overexpression of TLR4, and iv) higher superoxide anion production and lipid peroxidation index in association with increased levels of gp91phox and p47phox (NOX2) and NOX4. Pretreatment with dietary (−)-epicatechin prevented the adverse effects of LPS challenge essentially by inhibiting TLR4 upregulation and NOX activation and the consequent downstream events, e.g. NF-kB activation.
登录
查看更多内容
影响因子：
5.6
作者：
Aimo, Lucila;Mackenzie, Gerardo G.;Keenan, Alison H.;Oteiza, Patricia I.
通讯作者：
Oteiza, Patricia I.
影响因子：
7.4
作者：
Litterio, Maria C.;Jaggers, Grayson;Galleano, Monica
通讯作者：
Galleano, Monica
DOI：
10.1152/ajprenal.00414.2005
发表时间：
2006-05-01
影响因子：
4.2
作者：
El-Achkar, TM;Huang, XP;Dagher, PC
通讯作者：
Dagher, PC
DOI：
10.1152/ajprenal.00278.2010
发表时间：
2011-01-01
影响因子：
4.2
作者：
Giani, Jorge F.;Munoz, Marina C.;Dominici, Fernando P.
通讯作者：
Dominici, Fernando P.
影响因子：
4.5
作者：
Basciano, Heather;Federico, Lisa;Adeli, Khosrow
通讯作者：
Adeli, Khosrow