DISCRIMINATIVE CONTROL OF OPERANT-BEHAVIOR BY INTRAVENOUS ADMINISTRATION OF DRUGS IN RATS
DISCRIMINATIVE CONTROL OF OPERANT-BEHAVIOR BY INTRAVENOUS ADMINISTRATION OF DRUGS IN RATS
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DOI：
10.1007/bf00426208
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发表时间：
1975-01-01
期刊：
影响因子：
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通讯作者：
ANDO, K
中科院分区：
文献类型：
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作者：
ANDO, K
训练大鼠辨别安非他明和盐水的刺激特性。在静脉注射安非他明后按压杠杆后给予食物补充剂，但在注射盐水后不给予。随后在灭绝条件下的测试表明，大鼠在注入安非他明、甲基安非他明和可卡因后以高速率按压杠杆，但在盐水、乙醇、肾上腺素或戊巴比妥钠后以低速率按压杠杆。类似的程序表明，大鼠也可以区分乙醇和盐水。这些发现证实了早期的结果表明，静脉注射药物可以作为控制操作性行为的区别刺激。
Rats were trained to discriminate the stimulus properties of amphetamine and saline. Food reinforcer was given after lever pressing following intravenous amphetamine infusions but not following saline infusions. Subsequent tests under extinction conditions showed that rats pressed a lever at a high rate following infusions of amphetamine, methamphetamine and cocaine, but at a low rate following saline, ethanol, epinephrine or sodium pentobarbital. Similar procedures indicated that rats could also discriminate between ethanol and saline. These findings confirm earlier results indicating that intravenously administered drug can act as discriminative stimuli in controlling operant behavior.