Phospholipid hydroperoxide glutathione peroxidase gene is regulated via an estrogen and estrogen receptor signaling in cultured mouse fetuses
Phospholipid hydroperoxide glutathione peroxidase gene is regulated via an estrogen and estrogen receptor signaling in cultured mouse fetuses
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DOI：
10.1007/s11626-011-9438-z
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发表时间：
2011-09-01
影响因子：
2.1
通讯作者：
Nam, Sang-Yoon
中科院分区：
文献类型：
--
作者：
Baek, In-Jeoung;Jung, Ki Youn;Nam, Sang-Yoon
Although it has been suggested that the transcription of phospholipid hydroperoxide glutathione peroxidase (PHGPx), an essential antioxidant selenoenzyme, may be affected by the estrogen state in mammals, the direct mechanism underlying the regulation of the PHGPx gene by estrogens in mammalian tissues remains to be clearly elucidated. In this study, we evaluated the expression of the PHGPx mRNA in cultured mouse fetuses (embryonic days 8.5-10.5) exposed to 17 beta-estradiol (E-2; 0.1, 1, 10, 100, and 1,000 ng/ml); estrogen receptor (ER) agonists [ propyl pyrazole triol (PPT, an ER alpha-selective ligand, 1 mu l/ml) and diarylpropionitrile (DPN, an ER beta-selective ligand, 1 mu l/ml)]; and/or ER antagonist [ICI 182,780 (ICI, 1 mu l/ml)] using a whole embryo culture system. E-2-alone treatment significantly stimulated the expressions of both ER alpha and ER beta mRNAs in all the cultured fetuses (p
