Effect of MAL-photodynamic therapy on hypertrophic scarring
Effect of MAL-photodynamic therapy on hypertrophic scarring
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DOI：
10.1016/j.pdpdt.2010.07.003
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发表时间：
2010-09-01
影响因子：
3.3
通讯作者：
Curnow, A.
中科院分区：
文献类型：
--
作者：
Campbell, S. M.;Tyrrell, J.;Curnow, A.
背景资料：接受氨基乙酰丙酸（ALA）/甲基氨基乙酰丙酸（MAL）-光动力疗法（PDT）的局限性硬皮病患者显示皮肤紧绷度降低，表明该疗法可减少皮肤硬化[1]。Karrer及其同事每周一次或两次用5-ALA-PDT治疗患者，持续3 - 6个月，据报道，所有患者的治疗对皮肤斑块都非常有效。鉴于PDT在减少皮肤硬化方面的潜在益处，以下研究着眼于局部PDT对瘢痕形成机制的可能临床和组织学影响，特别是对增生性瘢痕。方法：患有长期增生性瘢痕的患者用MAL-PDT治疗两次，间隔一周，并以6周的间隔重复3次。在治疗过程中通过荧光成像研究PDT效应，并在治疗前和治疗后6周取活检组织观察组织学变化。治疗后6周，瘢痕区域显著软化，临床上和组织学上弹性蛋白纤维显著增加，变得更加柔韧。PDT可能是治疗瘢痕的有效治疗或辅助治疗。(C)2010 Elsevier B.V.保留所有权利。
Background: Patients with localised scleroderma receiving aminolevulinic acid (ALA)/methyl aminolevulinic acid (MAL)-photodynamic therapy (PDT) were noted to show a reduction in skin tightness, suggesting that this therapy reduces skin sclerosis [1]. Karrer and colleagues treated patients with 5-ALA-PDT once or twice weekly for 3-6 months and in all patients the therapy was reported to be highly effective for sclerotic plaques.In view of the potential benefit of PDT in reducing skin sclerosis, the following study looks at the possible clinical and histological effects of topical PDT on the mechanism of scarring, looking particularly at hypertrophic scars.Methods: Patients with long standing hypertrophic scars were treated with MAL-PDT on two occasions at week apart, and repeated for 3 sessions at 6-weekly intervals. PDT effect was studied by means of fluorescence imaging throughout the treatment and biopsies were taken prior to and 6 weeks post-treatment to observe histological changes.Results and conclusions: Six weeks following the treatment the scarred areas had significantly softened and become more flexible clinically and histologically there had been a significant increase in elastin fibres.This suggests that ALA/MAL-PDT may be a useful treatment or adjuvant therapy in the treatment of scarring. (C) 2010 Elsevier B.V. All rights reserved.