Modelling of the break force of tablets under diametrical compression.
Modelling of the break force of tablets under diametrical compression.
复制标题
直径压缩下片剂断裂力的建模。
DOI：
10.1016/j.ijpharm.2013.01.032
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发表时间：
2013
影响因子：
5.8
通讯作者：
Jingzhe Pan
中科院分区：
文献类型：
--
作者：
C. Shang;I. C. Sinka;Jingzhe Pan
提出了一种预测曲面片剂破断力的数值方法。确定了获得与实验数据一致的预测所需的本构模型和失效准则。一个修改后的Drucker-Prager帽模型连同最大主应力为基础的故障标准被发现足以预测径向压缩载荷下的片剂的断裂力。该方法的有效性的条件进行了鉴定，参考实际片剂的形状和故障模式。在这些条件下的数值程序可以被用来作为一个实用的工具来预测片剂破损作为替代目前用于药品设计和工艺开发的经验方法。
A numerical method to predict the break force of curved faced tablets is proposed. The constitutive model and the failure criteria necessary to obtain predictions consistent with experimental data are identified. A modified Drucker–Prager cap model together with a maximum principal stress based failure criteria was found sufficient to predict the break force of tablets under diametrical compression loading. The conditions for the validity of the method were identified with reference to practical tablet shapes and failure patterns. Under these conditions the numerical procedures can be used as a practical tool to predict tablet breakage as an alternative to the empirical methods currently used in pharmaceutical product design and process development.
使用材料点法对圆盘颗粒的脆性冲击破坏进行建模
影响因子：
5.1
作者：
Li F
通讯作者：
Li F