The Evolutionarily Stable Distribution of Fitness Effects
The Evolutionarily Stable Distribution of Fitness Effects
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适应度效应的进化稳定分布
DOI：
10.1101/013052
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发表时间：
2014
期刊：
影响因子：
3.3
通讯作者：
Michael M. Desai
中科院分区：
文献类型：
--
作者：
D. P. Rice;Benjamin H. Good;Michael M. Desai
The distribution of fitness effects (DFE) of new mutations is a key parameter in determining the course of evolution. This fact has motivated extensive efforts to measure the DFE or to predict it from first principles. However, just as the DFE determines the course of evolution, the evolutionary process itself constrains the DFE. Here, we analyze a simple model of genome evolution in a constant environment in which natural selection drives the population toward a dynamic steady state where beneficial and deleterious substitutions balance. The distribution of fitness effects at this steady state is stable under further evolution and provides a natural null expectation for the DFE in a population that has evolved in a constant environment for a long time. We calculate how the shape of the evolutionarily stable DFE depends on the underlying population genetic parameters. We show that, in the absence of epistasis, the ratio of beneficial to deleterious mutations of a given fitness effect obeys a simple relationship independent of population genetic details. Finally, we analyze how the stable DFE changes in the presence of a simple form of diminishing-returns epistasis.
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影响因子：
3.3
作者：
S. Sawyer;D. Hartl
通讯作者：
S. Sawyer;D. Hartl
DOI：
10.1073/pnas.0907953107
发表时间：
2010-03-02
影响因子：
11.1
作者：
Mustonen, Ville;Laessig, Michael
通讯作者：
Laessig, Michael
影响因子：
1.4
作者：
Rouzine, Igor M.;Brunet, Eric;Wilke, Claus O.
通讯作者：
Wilke, Claus O.
DOI：
10.1098/rstb.2009.0266
发表时间：
2010-04-27
影响因子：
6.3
作者：
Keightley, Peter D.;Eyre-Walker, Adam
通讯作者：
Eyre-Walker, Adam
影响因子：
3.3
作者：
Schiffels S;Szöllosi GJ;Mustonen V;Lässig M
通讯作者：
Lässig M