Regulation of the timing of oligodendrocyte differentiation: mechanisms and perspectives.

Regulation of the timing of oligodendrocyte differentiation: mechanisms and perspectives.
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少突胶质细胞分化时间的调控:机制和观点

DOI:
10.1007/s12264-013-1314-2
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发表时间:
2013-04
影响因子:
5.6
通讯作者:
Qiu, Mengsheng
Qiu, Mengsheng
中科院分区:
医学2区
文献类型:
--
作者:
Huang, Hao;Zhao, Xiao-Feng;Zheng, Kang;Qiu, Mengsheng

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轴突髓鞘形成是脊椎动物中枢神经系统正常功能的重要过程。轴突周围髓鞘的正确形成依赖于少突胶质细胞的及时分化。这种差异在文化和发育过程中都是按可预见的时间表发生的。然而,少突胶质细胞在正常发育过程中分化的时间机制还没有完全被发现。最近的研究已经确定了大量的调控因素,包括细胞内因素和细胞外信号,它们可以控制少突胶质细胞分化的时机。在此,我们对少突胶质细胞分化的时间调控进行了机械和关键的综述。
Axonal myelination is an essential process for normal functioning of the vertebrate central nervous system. Proper formation of myelin sheaths around axons depends on the timely differentiation of oligodendrocytes. This differentiation occurs on a predictable schedule both in culture and during development. However, the timing mechanisms for oligodendrocyte differentiation during normal development have not been fully uncovered. Recent studies have identified a large number of regulatory factors, including cell-intrinsic factors and extracellular signals, that could control the timing of oligodendrocyte differentiation. Here we provide a mechanistic and critical review of the timing control of oligodendrocyte differentiation.
NOTCH1控制脊髓中的少突胶质细胞分化。
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