STUDIES ON PULMONARY SECRETIONS. I. THE OVER-ALL CHEMICAL COMPOSITION OF PULMONARY SECRETIONS FROM PATIENTS WITH CYSTIC FIBROSIS, BRONCHIECTASIS, AND LARYNGECTOMY.
STUDIES ON PULMONARY SECRETIONS. I. THE OVER-ALL CHEMICAL COMPOSITION OF PULMONARY SECRETIONS FROM PATIENTS WITH CYSTIC FIBROSIS, BRONCHIECTASIS, AND LARYNGECTOMY.
复制标题
肺部分泌物的研究。
DOI：
10.1164/arrd.1963.88.2.199
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发表时间：
1963
期刊：
影响因子：
--
通讯作者：
Potter Jl
中科院分区：
文献类型：
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作者：
L. Matthews;S. Spector;J. Lemm;Potter Jl
囊性纤维化患者护理中的主要问题之一是预防复发的呼吸道感染。最终，在大多数情况下，导致这种疾病死亡的是肺功能的尴尬。目前，肺分泌物在肺部病变发生中的作用尚不清楚。有人认为，由于粘稠度的增加，支气管分泌物会产生阻塞，随后可能会发生感染。另外，囊性纤维化患者的肺分泌物可能为细菌的生长和增殖提供了更好的培养基。显然，对肺分泌物的进一步了解将为该病的发病机制和治疗提供迫切需要的洞察力。直到最近，关于肺分泌物的化学成分和物理性质的研究很少。Basch和他的同事(1)在1941年定义和分析了从支气管扩张症患者身上获得的粘液。冯·海斯林(2)和威尔斯(3)总结了与粘液化学成分有关的早期数据。沃纳(4)：研究了来自各种来源的粘液的化学性质，包括气管-支气管树。最近，Chernick和Barbero研究了囊性纤维化和支气管扩张症患者的气管和支气管分泌物的成分。丹顿(6)检查了痰的一些物理性质，特别是黏度。一份压缩文件-
One of the major problems in the care of patients with cystic fibrosis is the prevention of recurring respiratory infections. Ultimately, in most cases it is the embarrassment of pulmonary function which leads to death in this disease. The role of the pulmonary secretions in the production of the pulmonary lesion is not at present clear. It has been suggested that the bronchial secretions, because of increased viscosity, produce obstruction which may then be followed by infection. Alternatively, the pulmonary secretions of patients with cystic fibrosis might afford a better culture medium for the growth and proliferation of bacteria. It is evident that further understanding of the pulmonary secretions would provide much needed insight into the pathogenesis and treatment of this disorder.Until recently, very few studies have been carried out on the chemical composition and physical properties of pulmonary secretions. Basch and co-workers (1) defined and analyzed mucus obtained from patients with bronchiectasis in 1941. Von Haesslin (2) and Wells (3) have summarized the early data relating to the chemical composition of mucus. Werner (4)': has studied the chemical properties of mucus ifrom a variety of sources, including the tracheo-Ibronchial tree. More recently, Chernick and Barbero (5) have studied the composition of the~ racheobronchial secretions from individuals with cystic fibrosis and bronchiectasis. Denton (6) has examined some of the physical properties of sputum, particularly the viscosity. A compre-