Epidemiology of laboratory-confirmed influenza among kidney transplant recipients compared to the general population-A nationwide cohort study
Epidemiology of laboratory-confirmed influenza among kidney transplant recipients compared to the general population-A nationwide cohort study
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DOI：
10.1111/ajt.16421
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发表时间：
2021-02-19
影响因子：
8.8
通讯作者：
Finne, Patrik
中科院分区：
文献类型：
--
作者：
Helantera, Ilkka;Gissler, Mika;Finne, Patrik
季节性流感可引起器官移植后的发病和死亡。我们在全国队列中量化了肾移植受者中实验室确诊流感的检测，并与普通人群进行了比较。通过国家法定登记处的数据库链接，捕获了1995年至2017年期间我国所有肾移植受者中所有实验室确诊的流感病例和因流感住院的病例。来自芬兰总人口550万的数据被用于比较。计算流感年发病率、流感住院率和标准化发病率比（SIR）。共纳入3904名肾移植受者，总随访时间为37175例患者年。2003-2019年，实验室确认的流感发病率为每1000名患者年9.0例，2015-2019年为每1000名患者年18.0例。与一般人群相比，肾移植受者患实验室确诊流感的风险明显更高（SIR 5.1, 95% CI 4.5-5.7）。因流感住院的SIR为4.4 （95% CI 3.4-4.7）。住院患者死亡率为9%，实验室确诊流感患者死亡率为5%。与一般人群相比，肾移植受者检测到经实验室确认的流感增加了5倍，因流感住院的风险增加了4倍以上。
Seasonal influenza causes morbidity and mortality after organ transplantation. We quantified the detection of laboratory-confirmed influenza among kidney transplant recipients compared to the general population in a nationwide cohort. All laboratory-confirmed cases of influenza and hospitalizations due to influenza among all kidney transplant recipients in our country between 1995 and 2017 were captured with database linkage from statutory national registries. Data from the general population of Finland, population 5.5 million, were used for comparisons. Annual incidences of influenza and hospitalizations due to influenza, and standardized incidence ratios (SIR) were calculated. Altogether 3904 kidney transplant recipients with a total follow-up of 37 175 patient-years were included. Incidence of laboratory-confirmed influenza was 9.0 per 1000 patient years in 2003-2019, and 18.0 per 1000 patient years during 2015-2019. The risk of laboratory-confirmed influenza was significantly higher among kidney transplant recipients compared to the general population (SIR 5.1, 95% CI 4.5-5.7). SIR for hospitalization due to influenza was 4.4 (95% CI 3.4-4.7). Mortality of the hospitalized patients was 9%, and 5% of the patients with laboratory-confirmed influenza. Detection of laboratory-confirmed influenza is increased fivefold and risk of hospitalization due to influenza more than fourfold among kidney transplant recipients compared to the general population.