A high response is not essential to prevent selection bias: Results from the Leiden 85-plus study
A high response is not essential to prevent selection bias: Results from the Leiden 85-plus study
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DOI：
10.1016/s0895-4356(02)00505-x
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发表时间：
2002-11-01
影响因子：
7.2
通讯作者：
Westendorp, RGJ
中科院分区：
文献类型：
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作者：
Bootsma-van der Wiel, A;van Exel, E;Westendorp, RGJ
我们检验了一个假设，即在一个以社区为基础的队列研究中，增加应答率的额外努力将减少选择偏倚。在莱顿85岁以上的研究中，莱顿镇所有年满85岁的受试者都通过邮件被告知这项研究，然后通过电话被要求参加。在另一个招募阶段，对未直接参与的受试者进行了访问，并亲自要求其参与。当这些受试者拒绝时，会问一些无回答的问题。这样，我们收集了整个源人口的数据。在691例合格的老年受试者中，511例受试者（74%）直接参与。在那些没有直接参与的人中，88名受试者在额外的努力后参与了研究。反应率从74%上升到87%。与511名直接参与研究的受试者相比，88名经过额外努力后进入研究的受试者健康状况较差，生存率较低。拒绝的受试者更健康，情绪更差。直接样本与来源人群在社会人口统计学、健康和死亡率方面没有差异。总之，我们表明，给予适度高的直接反应，额外的努力是有效的，在增加响应率，但也是有选择性的，是没有必要防止选择偏差。(C)2002年爱思唯尔科技有限公司All rights reserved.
We tested the hypothesis that an additional effort to increase the response rate would diminish selection bias in a community-based cohort study. In the Leiden 85-plus Study, all subjects of the town of Leiden who had reached their 85th birthday were informed of the study by mail and then asked to participate by telephone. In an additional recruitment stage, those subjects who did not participate directly were visited and personally asked to participate. When these subjects refused, some nonresponse questions were asked. In this way we collected data on the whole source population. Of 691 eligible elderly subjects, 511 subjects (74%) participated directly. Of those who did not participate directly, 88 subjects participated after the additional effort. The response rate increased from 74% to 87%. Compared to the 511 subjects who directly particpated, the 88 subjects who entered the sudy after the additional effort had poorer health and lower survival. The subjects who refused were more healthy and had poorer mood. The direct sample did not differ from the source population with respect to socio-demographics, health, and mortality. In conclusion, we showed that given a moderately high direct response the additional effort was effective in increasing the response rate, but was also selective and was not necessary to prevent selection bias. (C) 2002 Elsevier Science Inc. All rights reserved.