Recovery of spermatogenesis following bone marrow transplantation
Recovery of spermatogenesis following bone marrow transplantation
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DOI：
10.1038/sj.bmt.1701332
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发表时间：
1998-08-01
影响因子：
4.8
通讯作者：
Holmes, J
中科院分区：
文献类型：
--
作者：
Jacob, A;Barker, H;Holmes, J
骨髓移植中使用的预备方案通常会导致男性生育能力的损害。虽然以化疗为基础的方案更有可能恢复生育能力，但在含创伤性脑损伤方案后，这种情况很少发生。我们对1984年至1995年间接受同种异体和自体骨髓或外周干细胞移植的男性进行了精子发生恢复的横断研究。我们确定了42例符合分析条件的患者中有6例恢复了生育能力或精子发生。精液分析显示，25名患者中有4名恢复了精子数量。这对患者咨询、移植后随访和避孕建议具有重要意义。
Preparative regimens used in bone marrow transplantation usually result in impairment of male fertility. Although recovery of fertility is more likely after chemotherapy-based regimens, this is a rare occurrence after TBI containing regimens, We undertook a cross-sectional study of recovery of spermatogenesis in men who had undergone allogeneic and autologous marrow or peripheral stem cell transplant between 1984 and 1995. We identified six out of 42 patients eligible for analysis to have either recovered fertility or spermatogenesis. Seminal fluid analysis showed that four out of 25 patients recovered sperm counts. This has important implications for patient counselling, post-transplant follow-up and contraceptive advice.