Intracerebroventricular insulin produces nonuniform regional increases in sympathetic nerve activity.
Intracerebroventricular insulin produces nonuniform regional increases in sympathetic nerve activity.
复制标题
脑室内胰岛素使交感神经活动产生不均匀的区域性增加。
DOI：
10.1152/ajpregu.1994.267.5.r1350
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Johnson,AK
中科院分区：
文献类型：
--
作者：
Muntzel,MS;Morgan,DA;Mark,AL;Johnson,AK
胰岛素已被证明可以增加交感神经活动（SNA）。虽然已经提出胰岛素在中枢神经系统（CNS）内增加交感神经流出，但很少有证据表明胰岛素对中枢神经的直接交感兴奋作用。为了确定脑室内胰岛素是否引起外周SNA的增加，我们将胰岛素（0.1微u /min，低剂量；10微u /min，中剂量；100微u /min，高剂量）或人工脑脊液（aCSF）注入氯氯糖麻醉的Wistar大鼠的第三脑室，同时记录腰椎SNA。在不同的动物中，注射10 μ u /min的胰岛素，同时记录肾上腺SNA和肾脏SNA。脑室内注射胰岛素后，血糖和血浆胰岛素水平无明显变化。腰椎SNA，以基线百分比表示，在注射aCSF的大鼠中（+ 13% +/- 8%）没有变化，但在注射低剂量（+ 72 +/- 17%）、中剂量（+ 119 +/- 30%）和高剂量（+ 113 +/- 25%）胰岛素的大鼠中显著增加（P < 0.05）。脑室注射胰岛素不能显著提高肾上腺SNA或肾SNA。在胰岛素输注期间血压和心率没有变化。结果表明，在没有血糖或血浆胰岛素变化的情况下，胰岛素注入第三脑室产生交感神经流出的区域不均匀增加。
Insulin has been shown to increase sympathetic nerve activity (SNA). Although it has been proposed that insulin acts within the central nervous system (CNS) to increase sympathetic neural outflow, there is little evidence for direct central neural sympathoexcitatory effects of insulin. To determine whether intracerebroventricular insulin elicits increases in peripheral SNA, we infused insulin (0.1 microU/min, low; 10 microU/min, medium; and 100 microU/min, high doses) or artificial cerebrospinal fluid (aCSF) into the third cerebral ventricle of chloralose-anesthetized Wistar rats while recording lumbar SNA. In separate animals, 10 microU/min of insulin were infused while recording adrenal SNA and renal SNA. Blood glucose and plasma insulin levels did not significantly change during intracerebroventricular infusion of insulin. Lumbar SNA, expressed as percentage of baseline, did not change in rats infused with aCSF (+ 13% +/- 8%) but increased significantly in rats infused with low (+ 72 +/- 17%), medium (+ 119 +/- 30%), and high (+ 113 +/- 25%) doses of insulin (P < 0.05). Intracerebroventricular insulin failed to significantly increase adrenal SNA or renal SNA. Blood pressure and heart rate did not change during insulin infusion. The results indicate that administration of insulin into the third cerebral ventricle produces regionally nonuniform increases in sympathetic neural outflow in the absence of changes in blood glucose or plasma insulin.