"Notch-Off": a perspective on the termination of Notch signalling
"Notch-Off": a perspective on the termination of Notch signalling
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DOI：
10.1387/ijdb.072309rf
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发表时间：
2009-01-01
影响因子：
0.7
通讯作者：
Henrique, Domingos
中科院分区：
文献类型：
--
作者：
Fior, Rita;Henrique, Domingos
在Notch介导的侧向抑制期间，相互作用的细胞建立或放大Notch信号传导的差异，然后根据发育背景将其转化为不同的细胞命运决定。近年来，已经发现了几种增加相互作用细胞的信号传导能力的机制（综述于Bray，2006，Le Borgne，2006，Schweisguth，2004）。然而，专门针对下调受体活性的机制也在侧抑制过程中发挥作用，决定性地导致相互作用细胞之间产生明确的差异。在这篇综述中，我们讨论了一些这些机制及其相关的整体架构的Notch途径。我们进一步强调了在由该途径介导的细胞命运决定过程中正确终止Notch活性的重要性。
During Notch mediated lateral inhibition, interacting cells establish or amplify differences in Notch signalling, which are then translated into distinct cell fate decisions according to the developmental context. In recent years, several mechanisms that increase the signalling capacity of interacting cells have been uncovered (reviewed in Bray, 2006, Le Borgne, 2006, Schweisguth, 2004). However, mechanisms specifically targeted to downregulate receptor activity are also at work during lateral inhibition, contributing decisively to generate definitive differences between interacting cells. In this review, we discuss some of these mechanisms and their relevance for the overall architecture of the Notch pathway. We further highlight the importance of properly terminating Notch activity during cell fate decisions mediated by this pathway.