Evidence of central inflammation in fibromyalgia - Increased cerebrospinal fluid interleukin-8 levels
Evidence of central inflammation in fibromyalgia - Increased cerebrospinal fluid interleukin-8 levels
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DOI：
10.1016/j.jneuroim.2011.10.013
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发表时间：
2012-01-18
影响因子：
3.3
通讯作者：
Kosek, Eva
中科院分区：
文献类型：
--
作者：
Kadetoff, Diana;Lampa, Jon;Kosek, Eva
据推测，在纤维肌痛等慢性疼痛综合征中，神经胶质细胞的激活导致鞘内细胞因子和趋化因子的升高。据我们所知，这是第一项评估纤维肌痛中促炎物质鞘内浓度的研究。我们报告 FM 患者脑脊液和血清中白细胞介素 8 浓度升高，但白细胞介素 1β 浓度不升高。该谱与由交感神经活动介导的 FM 症状相一致，而不是依赖于前列腺素相关机制，并支持神经胶质细胞激活响应疼痛机制的假设。 (C) 2011 Elsevier B.V. 保留所有权利。
Activation of glia cells resulting in intrathecal elevation of cytokines and chemokines has been hypothesized in chronic pain syndromes such as fibromyalgia. To our knowledge, this is the first study assessing intrathecal concentrations of pro-inflammatory substances in fibromyalgia. We report elevated cerebrospinal fluid and serum concentrations of interleukin-8, but not interleukin-1beta, in FM patients. This profile is in accordance with FM symptoms being mediated by sympathetic activity rather than dependent on prostaglandin associated mechanisms and supports the hypothesis of glia cell activation in response to pain mechanisms. (C) 2011 Elsevier B.V. All rights reserved.