THE TYPE 1 EGFR-RELATED FAMILY OF GROWTH FACTOR RECEPTORS AND THEIR LIGANDS
THE TYPE 1 EGFR-RELATED FAMILY OF GROWTH FACTOR RECEPTORS AND THEIR LIGANDS
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DOI：
10.1016/0955-2235(92)90002-y
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发表时间：
1992-01-01
期刊：
影响因子：
--
通讯作者：
LEMOINE N R
中科院分区：
文献类型：
--
作者：
PRIGENT S A;LEMOINE N R
本文综述了1型生长因子受体家族的生物学特性，该家族在控制正常细胞增殖和人类癌症发病机制中发挥着越来越重要的作用。该家族目前包括三个密切相关的成员：表皮生长因子(EGF)受体、c-erbB-2和c-erbB-3，所有这些成员在各种人类肿瘤中都显示出异常的表达。与EGF相关的因子家族最近也有所扩大，现在包括转化生长因子α、肝素结合EGF、双调蛋白、Cripto和hereglin，以及其他几个潜在的c-erbB-2受体配体。这些受体和生长因子在人类癌症中的参与对设计新的癌症治疗形式具有重要意义，我们回顾了最近的研究进展和未来的研究途径。
This review considers the biology of the type 1 growth factor receptor family which is increasingly recognised as important in the control of normal cell proliferation and in the pathogenesis of human cancer. The family currently comprises three closely related members: the epidermal growth factor (EGF) receptor, c-erbB-2 and c-erbB-3, all of which show abnormalities of expression in various human tumours. The family of factors related to EGF has also expanded recently and now includes transforming growth factor alpha, heparin-binding EGF, amphiregulin, cripto and heregulin, as well as several other potential ligands for the c-erbB-2 receptor. The involvement of these receptors and growth factors in human cancer has implications for the design of novel forms of therapy for cancer, and we review recent advances and future avenues for investigation.