Continuous detection of cerebral vasodilatation and vasoconstriction using intracranial pulse morphological template matching.
Continuous detection of cerebral vasodilatation and vasoconstriction using intracranial pulse morphological template matching.
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DOI：
10.1371/journal.pone.0050795
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Hu X
中科院分区：
文献类型：
--
作者：
Asgari S;Gonzalez N;Subudhi AW;Hamilton R;Vespa P;Bergsneider M;Roach RC;Hu X
虽然准确和连续的评估脑血管系统的状态是非常可取的管理脑血管疾病，没有这样的方法存在于目前的临床实践。本文介绍了一种利用脉冲形态模板匹配实时检测脑血管舒张和收缩的新方法。模板组成的脑血流速度（CBFV）脉冲，使用经颅多普勒在大脑中动脉测量的形态指标，通过应用形态聚类和分析颅内脉冲算法的数据收集在诱导血管舒张和血管收缩在受控设置。然后采用这些模板来定义任何查询数据段的血管舒张指数（VCI）和血管收缩指数（VCI），作为表现出与从训练数据集获得的趋势一致的趋势的度量的百分比。在过度通气（和CO2再呼吸试验）期间，采用与训练数据集相似的协议收集的27名健康受试者的CBFV信号数据集上，所提出的方法的验证分别显示出检测血管舒张（和血管收缩）的92%（和82%）的灵敏度和90%（和92%）的特异性。此外，所提出的检测血管舒张（血管收缩）的方法能够拒绝与血管收缩（血管舒张）相关的所有病例，并且对于血管舒张，其性能优于其他两种常规技术至少7%，对于血管收缩，其性能优于其他两种常规技术19%。
Although accurate and continuous assessment of cerebral vasculature status is highly desirable for managing cerebral vascular diseases, no such method exists for current clinical practice. The present work introduces a novel method for real-time detection of cerebral vasodilatation and vasoconstriction using pulse morphological template matching. Templates consisting of morphological metrics of cerebral blood flow velocity (CBFV) pulse, measured at middle cerebral artery using Transcranial Doppler, are obtained by applying a morphological clustering and analysis of intracranial pulse algorithm to the data collected during induced vasodilatation and vasoconstriction in a controlled setting. These templates were then employed to define a vasodilatation index (VDI) and a vasoconstriction index (VCI) for any inquiry data segment as the percentage of the metrics demonstrating a trend consistent with those obtained from the training dataset. The validation of the proposed method on a dataset of CBFV signals of 27 healthy subjects, collected with a similar protocol as that of training dataset, during hyperventilation (and CO2 rebreathing tests) shows a sensitivity of 92% (and 82%) for detection of vasodilatation (and vasoconstriction) and the specificity of 90% (and 92%), respectively. Moreover, the proposed method of detection of vasodilatation (vasoconstriction) is capable of rejecting all the cases associated with vasoconstriction (vasodilatation) and outperforms other two conventional techniques by at least 7% for vasodilatation and 19% for vasoconstriction.
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影响因子：
8.3
作者：
Subudhi, Andrew W.;Panerai, Ronney B.;Roach, Robert C.
通讯作者：
Roach, Robert C.
DOI：
10.1109/tbme.2008.2008636
发表时间：
2009-03
期刊：
IEEE transactions on bio-medical engineering
影响因子：
--
作者：
Hu X;Xu P;Scalzo F;Vespa P;Bergsneider M
通讯作者：
Bergsneider M
影响因子：
3.2
作者：
Scalzo, Fabien;Xu, Peng;Asgari, Shadnaz;Bergsneider, Marvin;Hu, Xiao
通讯作者：
Hu, Xiao
影响因子：
3.2
作者：
Panerai, R. B.;Salinet, A. S. M.;Robinson, T. G.
通讯作者：
Robinson, T. G.
影响因子：
3.5
作者：
Asgari, Shadnaz;Bergsneider, Marvin;Hamilton, Robert;Vespa, Paul;Hu, Xiao
通讯作者：
Hu, Xiao