Secretor and Salivary ABO Blood Group Antigen Status Predict Rotavirus Vaccine Take in Infants
Secretor and Salivary ABO Blood Group Antigen Status Predict Rotavirus Vaccine Take in Infants
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DOI：
10.1093/infdis/jix028
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发表时间：
2017-03-01
影响因子：
6.4
通讯作者：
Ali, Asad
中科院分区：
文献类型：
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作者：
Kazi, Abdul Momin;Cortese, Margaret M.;Ali, Asad
肠上皮细胞上表达的组织血型抗原（HBGAs）被认为是轮状病毒的受体，可以在唾液中检测到。在一项G1P [8]轮状病毒疫苗试验中，基线血清阴性的181名巴基斯坦婴儿中，3剂疫苗后抗轮状病毒免疫球蛋白A血清转换率因唾液HBGA表型而显著不同，非分泌型婴儿的血清转换率最低（19（即，不表达FUT2合成的碳水化合物），非O型血分泌者中的中间比例（30%），O型血分泌者阳性率最高（51%）。HBGA表达的差异可能是造成目前轮状病毒疫苗在低收入与高收入环境中检测到的保护水平差异的原因。
Histo-blood group antigens (HBGAs) expressed on enterocytes are proposed receptors for rotaviruses and can be measured in saliva. Among 181 Pakistani infants in a G1P[8] rotavirus vaccine trial who were seronegative at baseline, anti-rotavirus immunoglobulin A seroconversion rates after 3 vaccine doses differed significantly by salivary HBGA phenotype, with the lowest rate (19%) among infants who were nonsecretors (ie, who did not express the carbohydrate synthesized by FUT2), an intermediate rate (30%) among secretors with non-blood group O, and the highest rate (51%) among secretors with O blood group. Differences in HBGA expression may be responsible for some of the discrepancy in the level of protection detected for the current rotavirus vaccines in low-income versus high-income settings.