Lymphocyte migration into the central nervous system: Implication of ICAM-1 signalling at them blood-brain barrier
Lymphocyte migration into the central nervous system: Implication of ICAM-1 signalling at them blood-brain barrier
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DOI：
10.1016/s1537-1891(02)00199-4
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发表时间：
2002-06-01
影响因子：
4
通讯作者：
Couraud, PO
中科院分区：
文献类型：
--
作者：
Greenwood, J;Etienne-Manneville, S;Couraud, PO
淋巴细胞向中枢神经系统（CNS）募集是多发性硬化症（MS）、脑膜炎和后葡萄膜炎等疾病发病机制的关键步骤。控制淋巴细胞从血液中迁移的主要顺序阶段已被广泛报道，但直到最近才注意到血管内皮在积极支持跨血管迁移中的作用。现在已经证明，粘附分子，特别是免疫球蛋白超家族的分子（如ICAM-1， VCAM-1和PECAM-1）不仅作为白细胞受体的配体，而且还可以作为信号转导器。这些受体的参与启动内皮信号级联反应，导致下游效应机制，进而影响神经炎症的进展。特别是，研究表明，脑内皮细胞中icam -1介导的信号传导是淋巴细胞通过血脑屏障迁移过程中的一个关键调节步骤，因此代表了白细胞募集多步骤范式中的一个额外阶段。在这篇文章中，我们回顾了目前对内皮细胞ICAM-I信号传导的理解，并讨论了这些发现与白细胞转运到中枢神经系统的重要性。(C) 2002爱思唯尔科学有限公司版权所有。
Lymphocyte recruitment to the central nervous system (CNS) is a critical step in the pathogenesis of diseases such as multiple sclerosis (MS), meningitis and posterior uveitis. The principle sequential stages that control lymphocyte emigration from the blood have been widely reported, but only recently has attention been directed towards the role of the vascular endothelium in actively supporting transvascular migration. It has now been shown that adhesion molecules, particularly those of the immunoglobulin super family (eg ICAM-1, VCAM-1 and PECAM-1), not only act as ligands for leucocyte receptors but can also serve as signal transducers. Engagement of these receptors initiates endothelial signalling cascades that result in downstream effector mechanisms which in turn influence the progression of neuroinflammation. In particular, it has been shown that ICAM-1-mediated signalling in brain endothelial cells is a crucial regulatory step in the process of lymphocyte migration through the blood-brain barrier and as such represents an additional phase in the multistep paradigm of leucocyte recruitment. In this article we review current understanding of endothelial cell ICAM-I signalling and discuss the importance of these findings in relation to leucocyte trafficking to the CNS. (C) 2002 Elsevier Science Inc. All rights reserved.