Motor Imagery in Bipolar Depression With Slowed Movement
Motor Imagery in Bipolar Depression With Slowed Movement
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DOI：
10.1097/nmd.0b013e3182a5c2a7
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发表时间：
2013-10-01
影响因子：
1.9
通讯作者：
Wahlund, Bjorn
中科院分区：
文献类型：
--
作者：
Liberg, Benny;Adler, Mats;Wahlund, Bjorn
我们假设双相抑郁症的运动迟缓是由运动产生的前执行阶段的中断介导的。我们使用功能性磁共振成像来研究运动想象和运动执行过程中的神经活动，以阐明双相抑郁症患者（n = 9）与健康对照组（n = 12）相比，大脑中调节运动计划、准备和控制的区域是否被不同的激活。我们发现了显著的组间差异。在运动想象过程中，患者的后内侧顶叶皮层、后扣带皮层、前运动皮层、前额叶皮层和额极比对照组更活跃。参与运动选择、计划和准备的大脑区域的激活被改变了。此外，在双相抑郁伴运动发育迟滞的运动想象过程中，与自我参照和默认模式网络相关的边缘和前额叶区域发生了改变。
We hypothesized that motor retardation in bipolar depression is mediated by disruption of the pre-executive stages of motor production. We used functional magnetic resonance imaging to investigate neural activity during motor imagery and motor execution to elucidate whether brain regions that mediate planning, preparation, and control of movement are activated differently in subjects with bipolar depression (n = 9) compared with healthy controls (n = 12). We found significant between-group differences. During motor imagery, the patients activated the posterior medial parietal cortex, the posterior cingulate cortex, the premotor cortex, the prefrontal cortex, and the frontal poles more than the controls did. Activation in the brain areas involved in motor selection, planning, and preparation was altered. In addition, limbic and prefrontal regions associated with self-reference and the default mode network were altered during motor imagery in bipolar depression with motor retardation.