Rapid and in situ optical detection of trace lithium in tissues
Rapid and in situ optical detection of trace lithium in tissues
复制标题
DOI：
10.1364/boe.9.004459
复制
发表时间：
2018-09-01
影响因子：
3.4
通讯作者：
Lau, Condon
中科院分区：
文献类型：
--
作者：
Ahmed, Irfan;Yang, Jingwei;Lau, Condon
锂基药物已成功用于治疗许多精神疾病，包括双相情感障碍和阿尔茨海默病。然而，由于在器官和细胞中检测锂的局限性，治疗机制并没有很好地表征。这限制了改进锂基治疗的能力。为了满足这一需求，激光诱导击穿光谱（LIBS）被开发用于快速和原位检测生物组织中的锂。口服锂时，在大鼠甲状腺、唾液和乳腺670.7nm处观察到明显的锂辐射。还观察到钙、碳、镁、钠、钾和碘的排放。锂辐射强度与组织锂浓度呈正相关，接近于1ppm。锂的检出限确定为类似于0.1ppm。甲状腺锂强度增加，碘强度降低。治疗后甲状腺内碘的减少可能会损害激素的产生。此外，唾液腺和乳腺中锂的存在使这些腺体分别成为锂进入唾液和母乳的可能通道。LIBS非常适合描述锂和其他元素在人体中的分布。这种光学方法有可能适用于体内和人体。(C) 2018年美国光学学会根据OSA开放获取出版协议的条款
Lithium-based medications are used successfully to treat many mental disorders, including bipolar disorder and Alzheimer's disease. However, the therapeutic mechanisms are not well characterized due to limitations in detecting lithium in organs and cells. This limits the ability to improve lithium-based treatments. To address this need, laser-induced breakdown spectroscopy (LIBS) is developed for the rapid and in situ detection of lithium in biological tissues. Pronounced lithium emissions are observed at 670.7nm from the rat thyroid, salivary, and mammary glands when lithium is administered orally. Calcium, carbon, magnesium, sodium, potassium, and iodine emissions are also observed. The lithium emission intensity is positively correlated with tissue lithium concentration, which is similar to 1ppm. The limit of detection for lithium is determined to be similar to 0.1ppm. Thyroid lithium intensity increases while iodine intensity decreases. The reduced intrathyroidal iodine following treatment likely impairs hormone production. Further, the presence of lithium in the salivary and mammary glands makes these glands the likely conduits for lithium to enter the saliva and breast milk, respectively. LIBS is well suited for characterizing the distribution of lithium, and other elements, across the body. This optical method can potentially be adapted for use in vivo and in humans. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement