Respiratory infections drive hepcidin-mediated blockade of iron absorption leading to iron deficiency anemia in African children
Respiratory infections drive hepcidin-mediated blockade of iron absorption leading to iron deficiency anemia in African children
复制标题
呼吸道感染导致铁调素介导的铁吸收阻断，导致非洲儿童缺铁性贫血
作者：
A. Prentice;Amat Bah;M. Jallow;Amadou T Jallow;S. Sanyang;Ebrima A. Sise;Kabiru Ceesay;Ebrima Danso;A. Armitage;S. Pasricha;H. Drakesmith;M. Wathuo;Noah J. Kessler;C. Cerami;R. Wegmüller
呼吸道感染引起的炎症通过阻碍铁的吸收而导致儿童缺铁性贫血。缺铁性贫血（IDA）是世界范围内最普遍的营养状况。我们研究了铁调素介导的铁阻断对非洲儿童IDA的贡献。我们每周测量407名贫血（血红蛋白< 11 g/dl）的冈比亚儿童（6至27个月）的铁调素和血红蛋白，以及基线、7周和12周时的血液学、炎症和铁生物标志物。每个孩子都保持了非常稳定的铁调素水平（儿童间方差P < 0.0001），其中一半始终保持着表明铁吸收生理阻断的水平。护士归因的不良事件与呼吸道感染和发热的主要信号强烈预测铁调素（所有P < 0.0001）。腹泻和粪便钙卫蛋白与铁调素无关。在多变量分析中，C-反应蛋白是铁调素的主要预测因子，即使在非常低的水平下也有助于铁阻断。我们的结论是，即使是低度炎症，特别是与呼吸道感染，有助于IDA在非洲儿童。
Inflammation from respiratory infections contributes to iron deficiency anemia in children by blocking iron absorption. Iron deficiency anemia (IDA) is the most prevalent nutritional condition worldwide. We studied the contribution of hepcidin-mediated iron blockade to IDA in African children. We measured hepcidin and hemoglobin weekly, and hematological, inflammatory, and iron biomarkers at baseline, 7 weeks, and 12 weeks in 407 anemic (hemoglobin < 11 g/dl), otherwise healthy Gambian children (6 to 27 months). Each child maintained remarkably constant hepcidin levels (P < 0.0001 for between-child variance), with half consistently maintaining levels that indicate physiological blockade of iron absorption. Hepcidin was strongly predicted by nurse-ascribed adverse events with dominant signals from respiratory infections and fevers (all P < 0.0001). Diarrhea and fecal calprotectin were not associated with hepcidin. In multivariate analysis, C-reactive protein was the dominant predictor of hepcidin and contributed to iron blockade even at very low levels. We conclude that even low-grade inflammation, especially associated with respiratory infections, contributes to IDA in African children.
健康美国黑人与年龄和性别相关的血细胞值。
DOI：
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发表时间：
1987
期刊：
Public health reports (Washington, D.C. : 1974)
影响因子：
--
作者：
Castro,OL;Haddy,TB;Rana,SR
通讯作者：
Rana,SR
DOI：
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发表时间：
2017-07
期刊：
--
影响因子：
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作者：
T. Vos;A. Abajobir;C. Abbafati;K. Abbas;K. H. Abate;F. Abd-Allah;A. Abdulle;Teshome Abuka Abebo-
通讯作者：
T. Vos;A. Abajobir;C. Abbafati;K. Abbas;K. H. Abate;F. Abd-Allah;A. Abdulle;Teshome Abuka Abebo-
影响因子：
20.3
作者：
Rivera, S;Nemeth, E;Ganz, T
通讯作者：
Ganz, T