COMPARATIVE EFFECTS OF LONG-TERM ETHANOL CONSUMPTION AND FOREBRAIN LESIONS ON MAZE LEARNING AND ACTIVE AVOIDANCE BEHAVIOR IN RATS
COMPARATIVE EFFECTS OF LONG-TERM ETHANOL CONSUMPTION AND FOREBRAIN LESIONS ON MAZE LEARNING AND ACTIVE AVOIDANCE BEHAVIOR IN RATS
复制标题
DOI：
10.1016/0741-8329(84)90023-5
复制
发表时间：
1984-01-01
期刊：
影响因子：
2.3
通讯作者：
BRUMBACK R A
中科院分区：
文献类型：
--
作者：
BEATTY W W;BENGTSON K R;BRUMBACK R A
雄性大鼠食用含有10.7%乙醇的液体饲料作为其唯一的食物和液体来源，持续6.5个月。从2个月开始。年龄。在戒断过程中，酒精组和他们的配对喂养或自由喂养的控制脑电图，体温，易怒和震颤的措施之间没有差异。在戒断后4-5周开始的行为测试中，饮酒大鼠在交叉迷宫任务中获得准确的空间行为的速度比对照组慢，但在穿梭回避学习中未受损。在同时进行的研究中，大鼠组的背海马，乳头体（MMB），或mediodorsal丘脑的持续病变，MMB病变后的行为缺陷的模式被发现是定性类似于停止长期饮酒后观察到的。这些发现提供了新的希望，一个有用的啮齿动物模型，研究与人类酗酒相关的认知缺陷的神经心理学可以开发。
Male rats consumed a liquid diet containing 10.7% ethanol as their only source of food and fluid for 6.5 mo. beginning at 2 mo. of age. During withdrawal, there were no differences between the alcohol group and their pair-fed or free-fed controls on EEG, body temperature, irritability and tremor measures. In behavioral tests begun 4-5 wk after withdrawal, the rats that had consumed alcohol acquired accurate spatial behavior in a cross maze task more slowly than controls, but were uninpaired in shuttle-avoidance learning. In concurrent studies with groups of rats that had sustained lesions of the dorsal hippocampus, the mamillary bodies (MMB), or the mediodorsal thalamus, the pattern of behavioral deficits after MMB lesions was found to be qualitatively similar to that observed after the cessation of long-term alcohol consumption. These findings provide renewed hope that a useful rodent model for studying the neuropsychology of cognitive deficits associated with human alcoholism can be developed.