Mechanisms underlying pattern generation in lobster stomatogastric ganglion as determined by selective inactivation of identified neurons. I. Pyloric system.
Mechanisms underlying pattern generation in lobster stomatogastric ganglion as determined by selective inactivation of identified neurons. I. Pyloric system.
复制标题
通过选择性失活已识别的神经元来确定龙虾口胃神经节模式生成的机制。
DOI：
10.1152/jn.1980.44.6.1102
复制
发表时间：
1980
影响因子：
2.5
通讯作者：
Miller,JP
中科院分区：
文献类型：
--
作者：
Selverston,AI;Miller,JP
1. 龙虾口胃神经节幽门网络模式的产生有四个因素。它们是：a)内源性振荡神经元；B)突触网络特性；C)非线性细胞特性，包括平台电位的产生；d)来自联合神经节的兴奋性输入。这些因素的作用和相对重要性是通过一种新的技术来灭活单个特异性识别神经元。2. 在兴奋性输入保持完整的口胃神经节中，a)当除内源性爆裂器外的任何细胞或细胞对失活时，模式生成仍在继续；b)当内源性爆裂器失活时，模式生成也在继续；c)当内源性爆裂器加另一个特定细胞失活时，模式生成停止。该细胞虽然不是内源性爆发细胞，但具有产生平台电位的强烈倾向。3. 在与兴奋性输入分离的口胃神经节中，a)当除内源性爆裂器外的任何细胞或细胞对失活时，模式生成仍在继续；b)当内源性爆裂器失活时，模式生成停止。4. 一些输入口胃神经节的信号通常是爆发的。然而，它们的输出模式的增强和加速也是由神经的强直刺激产生的。其中一种输入的效果是通过在口胃神经节中大量应用多巴胺来模拟的。5. 三个最重要因素的作用和重要性定性地概括在一张图表中，该图表说明了网络的活动作为其完整性的函数。
1. Four factors contribute to pattern generation in the pyloric network of the lobster stomatogastric ganglion. These are: a) endogenously oscillating neurons; b) synaptic network properties; c) nonlinear cellular properties, including the generation of plateau potentials; and d) excitatory input from the commissural ganglia. The roles and relative importance of these factors were investigated with a new technique for inactivating single specific identified neurons. 2. In stomatogastric ganglia in which the excitatory input is left intact, a) pattern generation continues when any cell or pair of cells other than the endogenous bursters are inactivated, b) pattern generation also continues when the endogenous bursters are inactivated, c) pattern generation ceases when the endogenous bursters plus one other particular cell are inactivated. This cell, although not an endogenous burster, displays a strong tendency to generate plateau potentials. 3. In stomatogastric ganglia that have been isolated from excitatory input, a) pattern generation continues when any cell or pair of cells other than the endogenous bursters are inactivated, b) pattern generation ceases when the endogenous bursters are inactivated. 4. Some of the inputs to the stomatogastric ganglion normally fire in bursts. However, their potentiation and acceleration of the output pattern are also produced by tonic stimulation of the nerve. The effect of one of those inputs is mimicked by bath application of dopamine to the stomatogastric ganglion. 5. The roles and importance of the three most important factors were qualitatively summarized in a chart specifying the activity of the network as a function of its intactness.