Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study
Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study
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DOI：
10.3945/ajcn.111.022533
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发表时间：
2012-02-01
影响因子：
7.1
通讯作者：
Richelsen, Bjorn
中科院分区：
文献类型：
--
作者：
Maersk, Maria;Belza, Anita;Richelsen, Bjorn
背景：在观察性和短期干预研究中，蔗糖软饮料(SSSD)的消费与肥胖、代谢综合征和心血管疾病有关。目的：比较等热量牛奶和无热量软饮料对总脂肪质量和异位脂肪沉积(肝脏和肌肉组织中的脂肪沉积)的影响。设计：超重受试者(n=47)随机分为4种不同的试验饮料(1 L/d，6mo)：SSSD(普通可乐)、等卡路里半生牛奶、含阿斯巴甜的健怡可乐和水。用H-1磁共振波谱测定肝内脂肪和心肌细胞内脂肪的含量。结果：普通可乐组在6个月干预结束前和基线之间的相对变化显著高于其他3组：肝脏脂肪(132-143%，性别调整后平均值；P<；0.01)、骨骼肌脂肪(117-221%；P<；0.05)、内脏脂肪(24-31%；P<；0.05)、血甘油三酯(32%；P<；0.05；和总胆固醇(11%；P<；0.01)。总脂肪质量在4个饮料组之间没有显著差异。与普通可乐相比，牛奶和健怡可乐降低了10-15%的收缩压(P<；0.05)。结论：与牛奶、健怡可乐和水相比，每天摄入SSSD 6个月可增加异位脂肪堆积和血脂。因此，每天摄入SSSD可能会增加患心血管和代谢性疾病的风险。这项试验在Clinicaltrials.gov上注册为NCT00777647。Ant J Clin Nutr 2012；95：283-9。
Background: The consumption of sucrose-sweetened soft drinks (SSSDs) has been associated with obesity, the metabolic syndrome, and cardiovascular disorders in observational and short-term intervention studies. Too few long-term intervention studies in humans have examined the effects of soft drinks.Objective: We compared the effects of SSSDs with those of isocaloric milk and a noncaloric soft drink on changes in total fat mass and ectopic fat deposition (in liver and muscle tissue).Design: Overweight subjects (n = 47) were randomly assigned to 4 different test drinks (1 L/d for 6 mo): SSSD (regular cola), isocaloric semiskim milk, aspartame-sweetened diet cola, and water. The amount of intrahepatic fat and intramyocellular fat was measured with H-1-magnetic resonance spectroscopy. Other endpoints were fat mass, fat distribution (dual-energy X-ray absorptiometry and magnetic resonance imaging), and metabolic risk factors.Results: The relative changes between baseline and the end of 6-mo intervention were significantly higher in the regular cola group than in the 3 other groups for liver fat (132-143%, sex-adjusted mean; P < 0.01), skeletal muscle fat (117-221%; P < 0.05), visceral fat (24-31%; P < 0.05), blood triglycerides (32%; P < 0.01), and total cholesterol (11%; P < 0.01). Total fat mass was not significantly different between the 4 beverage groups. Milk and diet cola reduced systolic blood pressure by 10-15% compared with regular cola (P < 0.05). Otherwise, diet cola had effects similar to those of water.Conclusion: Daily intake of SSSDs for 6 mo increases ectopic fat accumulation and lipids compared with milk, diet cola, and water. Thus, daily intake of SSSDs is likely to enhance the risk of cardiovascular and metabolic diseases. This trial is registered at clinicaltrials.gov as NCT00777647. Ant J Clin Nutr 2012;95:283-9.