Electrospray ionization Fourier transform ion cyclotron resonance at 9.4 T.

Electrospray ionization Fourier transform ion cyclotron resonance at 9.4 T.
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DOI:
10.1002/(sici)1097-0231(199611)10:14
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发表时间:
1996
期刊:
Rapid communications in mass spectrometry : RCM
影响因子:
--
通讯作者:
M. Senko;C. Hendrickson;L. Paša-Tolić;J. Marto;F. White;S. Guan;A. G. Marshall
M. Senko;C. Hendrickson;L. Paša-Tolić;J. Marto;F. White;S. Guan;A. G. Marshall
中科院分区:
其他
文献类型:
--
作者:
M. Senko;C. Hendrickson;L. Paša-Tolić;J. Marto;F. White;S. Guan;A. G. Marshall

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我们展示了新型电喷雾电离傅里叶变换离子回旋共振质谱仪的第一个结果,该质谱仪在 9.4 T 的磁场下运行(即比任何现有 FTICR 仪器高 > 或 = 2.4 T)。与低场(200,000,通常用于猪血清白蛋白(67 kDa))相比,9.4 T 仪器为大分子(质量分辨能力增加 > 或 = 50% 增加)和复杂混合物(动态范围增加 > 或 = 100%)提供了显着改进的性能。目前的性能指导了仪器的进一步修改,这应该会带来显着的进一步改进。
We present the first results from a new electrospray ionization Fourier transform ion cyclotron resonance mass spectrometer operated at a magnetic field of 9.4 T (i.e. > or = 2.4 T higher than for any prior FTICR instrument). The 9.4 T instrument provides substantially improved performance for large molecules (> or = 50% increase in mass resolving power) and complex mixtures (> or = 100% increase in dynamic range) compared to lower-field ( 200,000, routinely for porcine serum albumin (67 kDa). The present performance guides further modifications of the instrument, which should lead to significant further improvements.