Utility of a new assay for carbohydrate-deficient transferrin (BIORAD %CDT TIA) to monitor abstinence during a treatment outcome study
Utility of a new assay for carbohydrate-deficient transferrin (BIORAD %CDT TIA) to monitor abstinence during a treatment outcome study
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DOI：
10.1111/j.1530-0277.2001.tb02355.x
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发表时间：
2001-09-01
影响因子：
3.2
通讯作者：
Anton, RF
中科院分区：
文献类型：
--
作者：
Myrick, H;Henderson, S;Anton, RF
背景：可靠地检测大量酒精使用的能力在临床和研究人群中都很重要。本研究在一项治疗结果研究中评估了最新的碳水化合物缺乏转铁蛋白(CDT)测量方法在监测戒酒效果方面的有效性。方法：40名酒精依赖者在基线和治疗4、8、12周采集血液。结果：在第4周戒酒的受试者中，基线%CDT水平显著下降，在第8周和第12周有一种趋势。相反，饮酒者和戒酒者在任何时间点的基线GGT水平百分比没有显著差异。结论：尽管这项研究的规模很小，但本研究为在治疗结果研究中使用相对较新的Biorad%CDT检测方法来监测饮酒状态提供了初步证据。这项研究也与先前报道的结果一致，即GGT在检测酒精消费方面似乎不如%CDT敏感。一个更大规模的试验关注性别差异在%CDT监测结果中的作用将是有意义的。
Background: The ability to reliably detect heavy alcohol use is important in both clinical and research populations. The current study evaluates the utility of the newest method of measuring carbohydrate deficient transferrin (CDT) in monitoring the abstinence during a treatment outcome study.Methods: Blood from 40 alcohol dependent individuals was obtained at baseline and at weeks 4, 8, and 12 of treatment. Differences in percent of baseline GGT and %CDT levels were analyzed in people who remained abstinent throughout treatment (abstainers) and in those who consumed alcohol during treatment (drinkers).Results: There was a significant decrease in the percent of baseline %CDT levels in the subjects who abstained at week 4 and a trend at weeks 8 and 12. Conversely, there were no significant differences in percent of baseline GGT levels between drinkers and abstainers at any time point.Conclusions: Although small in nature, this study provides preliminary evidence for the use of the relatively new Biorad %CDT assay to monitor drinking status during treatment outcome studies. This study is also consistent with previously reported findings that GGT appears to be less sensitive than %CDT in detecting the consumption of alcohol. A larger trial focusing on sex differences in the utility of % CDT to monitor outcome would be of interest.