INTERMITTENT PATTERN OF NEURAL-TUBE CLOSURE IN 2 STRAINS OF MICE
INTERMITTENT PATTERN OF NEURAL-TUBE CLOSURE IN 2 STRAINS OF MICE
复制标题
DOI：
10.1002/tera.1420470112
复制
发表时间：
1993-01-01
期刊：
影响因子：
--
通讯作者：
CHERNOFF, GF
中科院分区：
文献类型：
--
作者：
GOLDEN, JA;CHERNOFF, GF
神经管的发育通常被描述为一个连续的过程，从胚胎的颈部区域开始，并向头侧和尾侧进行。对 LM/Bc 和 SWV/Bc 小鼠颅骨区域神经管闭合的检查显示出具有四个不同闭合区域的间歇模式。闭合 I 从体节 1-3 水平开始并双向进行。闭合 II 从前脑-中脑边界开始，并且也是双向进行的。闭合 III 是单向的，从邻近吻合口开始，向尾部延伸至闭合 II。最后，闭合 IV 发生在菱形脑上，与闭合 II 相交以完成吻端神经管闭合。在这两种小鼠品系中，前神经管闭合随着体节数量的增加而进展。然而，SWV 毒株需要更长的妊娠时间才能发育出相同数量的体节，从而完成闭合。鉴于在小鼠中观察到的间歇性闭合模式，应该重新考虑包括人类在内的其他哺乳动物的嘴神经系统的发育。
Development of the neural tube is often described as a continuous process that begins in the cervical region of the embryo and proceeds both rostrally and caudally. Examination of neural tube closure in the cranial region of LM/Bc and SWV/Bc mice revealed an intermittent pattern with four distinct areas of closure. Closure I begins at the level of somites 1-3 and proceeds bidirectionally. Closure II is initiated at the prosencephalic-mesencephalic border and also proceeds bidirectionally. Closure III is unidirectional, beginning adjacent to the stomodeum and proceeding caudally to meet closure II. Finally, closure IV takes place over the rhombencephalon where it meets closure II to complete rostral neural tube closure. In these two strains of mice anterior neural tube closure progressed as somite number increased. However, the SWV strain required a longer gestational time to develop equal numbers of somites and therefore to complete closure. In light of the intermittent pattern of closure observed in mice, the development of the rostral nervous system in other mammals, including humans, should be reconsidered.