Selective suppression of reactivity to rat histocompatibility antigens by hybridoma antibodies.
Selective suppression of reactivity to rat histocompatibility antigens by hybridoma antibodies.
复制标题
杂交瘤抗体选择性抑制对大鼠组织相容性抗原的反应性。
DOI：
10.1007/978-3-642-67448-8_10
复制
发表时间：
1978
影响因子：
--
通讯作者：
F. Fitch
中科院分区：
文献类型：
--
作者：
T. Mckearn;M. Sarmiento;A. Weiss;F. Stuart;F. Fitch
Alloimmune serum can selectively suppress humoral and cell-mediated immunity towards the histocompatibility antigens of inbred rats. In the case of renal allograft enhancement, the suppression induced by one injection of alloimmune serum often lasts for the life of the adult rat and displays striking immunological specificity (1,2). Due in part to the variability in biological effects of various pools of alloimmune serum, much controversy currently exists regarding the immunoglobulin class, alloantigen specificity and idiotypic repertoire of those alloantibodies which are presumed responsible for the suppressive effects of an effective alloantiserum (3,4). Hybridoma technology offers an unique opportunity to dissect the component imnunoglobulins of an immunized individual and study the biological effects of these hybridoma antibodies.
