Cadinane-type sesquiterpenes with potential anti-inflammatory and anti-HIV activities from the stems and leaves of Mappianthus iodoides
Cadinane-type sesquiterpenes with potential anti-inflammatory and anti-HIV activities from the stems and leaves of Mappianthus iodoides
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DOI：
10.1080/14786419.2021.1956921
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发表时间：
2021-07-16
影响因子：
2.2
通讯作者：
Fu, Yan-Hui
中科院分区：
文献类型：
--
作者：
Liu, Yan-Ping;Yu, Xiao-Mei;Fu, Yan-Hui
从假眼梅（Mappianthus iodoides）的茎叶中分离鉴定了8个杜松烷型倍半萜，其中包括一个新的杜松烷型倍半萜，命名为假眼梅（mappianiodene）（1）和7个已知类似物（2-8）。通过大量的光谱方法确定了化合物1的化学结构和绝对构型，并将已知化合物的实验光谱数据与文献报道的光谱数据进行了比较。对分离得到的杜松烷型倍半萜类化合物进行了抗炎和抗HIV活性测试。结果，杜松烷型倍半萜1-8对NO（一氧化氮）产生显示出显著的抑制作用，其IC 50值与氢化可的松的IC 50值相当。此外，化合物1-8显示出显著的抗HIV-1逆转录酶（RT）活性，EC 50值在0.17 - 9.28 μ M范围内。
Eight cadinane-type sesquiterpenes, including a new cadinane-type sesquiterpene, named as mappianiodene (1), and seven known analogues (2-8), were isolated and identified from the stems and leaves of Mappianthus iodoides. The chemical structure and absolute configurations of 1 was elucidated by extensive spectral methods and the known compounds were identified by comparing their experimental spectral data with the reported spectral data in the literature. The anti-inflammatory and anti-HIV activities of those isolated cadinane-type sesquiterpenes were tested. As a result, cadinane-type sesquiterpenes 1-8 displayed notable inhibitory effects on NO (nitric oxide) production with IC50 values equivalent to that of the hydrocortisone. Moreover, compounds 1-8 exhibited pronounced anti-HIV-1 reverse transcriptase (RT) activities with the EC50 values in range of 0.17 to 9.28 mu M.