Extravillous trophoblast apoptosis - A workshop report
Extravillous trophoblast apoptosis - A workshop report
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DOI：
10.1016/j.placenta.2005.02.002
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发表时间：
2005-04-01
期刊：
影响因子：
3.8
通讯作者：
Chamley, LW
中科院分区：
文献类型：
--
作者：
Huppertz, B;Hemmings, D;Chamley, LW
在正常妊娠期间，绒毛外滋养层细胞侵入母体子宫组织。间质滋养层穿透蜕膜组织到达子宫肌层的内三分之一。间质滋养层的一个子集，壁内/血管内滋养层将子宫螺旋动脉转化为大口径导管，以使胎盘和胎儿能够获得充足的营养和氧气。控制入侵仍然是一个谜，因此，在本研讨会报告中，已经存在的概念以及新的模型进行了讨论。母体细胞如巨噬细胞和内皮细胞对滋养层细胞的侵袭和凋亡有明显的影响。然而，滋养层细胞需要易于经历凋亡。因此，滋养层内的内在程序需要在外部诱导成功之前被激活。细胞凋亡的定量分析进一步阐明了间质滋养细胞的凋亡不是导致病理性浅表浸润的最终手段。另一方面，壁内/血管内滋养层细胞的凋亡似乎与螺旋动脉的正确转化高度相关。© 2005由IFPA和Elsevier Ltd.出版。
During normal pregnancy, extravillous trophoblast cells invade maternal uterine tissues. The interstitial trophoblast penetrates decidual tissues reaching the inner third of the myometrium. A subset of the interstitial trophoblast, the intramural/endovascular trophoblast transforms uterine spiral arteries into large-bore conduits to enable the adequate supply of nutrients and oxygen to the placenta and thus the fetus. Control of invasion is still a mystery and therefore, in this workshop report already existing concepts as well as new models are discussed. Maternal cells such as macrophages and endothelial cells have a clear impact on trophoblast invasion and apoptosis. However, the trophoblast cells need to be susceptible to undergo apoptosis. Thus, an intrinsic program within the trophoblast needs to be activated before induction from the outside can be successful. Quantification of apoptosis further clarified that apoptosis of interstitial trophoblast is not the ultimate means to lead to pathologically shallow invasion. On the other hand, apoptosis of intramural/endovascular trophoblast seems to be highly relevant for a correct transformation of spiral arteries. © 2005 Published by IFPA and Elsevier Ltd.