Adherence and motility characteristics of clinical Acinetobacter baumannii isolates
Adherence and motility characteristics of clinical Acinetobacter baumannii isolates
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DOI：
10.1111/j.1574-6968.2011.02362.x
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发表时间：
2011-10-01
影响因子：
2.1
通讯作者：
Brown, Melissa H.
中科院分区：
文献类型：
--
作者：
Eijkelkamp, Bart A.;Stroeher, Uwe H.;Brown, Melissa H.
鲍曼不动杆菌仍然是一个主要的健康问题，尤其是在医院环境中。在此，在来自澳大利亚的临床鲍曼不动杆菌菌株中研究了可能在持久性和疾病潜力中发挥作用的特征。抽搐运动被发现是鲍曼不动杆菌国际克隆 I 菌株和丰富的生物膜形成者的共同特征，而集群运动仅在未分类为国际克隆谱系的分离株中观察到。 IV 型菌毛的生物信息分析揭示了 PilA 序列同源性和运动性之间的相关性。发现对非生物表面和上皮细胞的粘附存在高度的可变性。我们首次报告了大量鲍曼不动杆菌分离株的运动特征，并直接比较了鲍曼不动杆菌与鼻咽和肺上皮细胞的结合。
Acinetobacter baumannii continues to be a major health problem especially in hospital settings. Herein, features that may play a role in persistence and disease potential were investigated in a collection of clinical A. baumannii strains from Australia. Twitching motility was found to be a common trait in A. baumannii international clone I strains and in abundant biofilm formers, whereas swarming motility was only observed in isolates not classified within the international clone lineages. Bioinformatic analysis of the type IV fimbriae revealed a correlation between PilA sequence homology and motility. A high level of variability in adherence to both abiotic surfaces and epithelial cells was found. We report for the first time the motility characteristics of a large number of A. baumannii isolates and present a direct comparison of A. baumannii binding to nasopharyngeal and lung epithelial cells.