Brief communication: Duration of platelet dysfunction after a 1-day course of ibuprofen
Brief communication: Duration of platelet dysfunction after a 1-day course of ibuprofen
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DOI：
10.7326/0003-4819-142-7-200504050-00009
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发表时间：
2005-04-05
影响因子：
39.2
通讯作者：
Manco-Johnson, MJ
中科院分区：
文献类型：
--
作者：
Goldenberg, NA;Jacobson, L;Manco-Johnson, MJ
背景资料：尽管缺乏证据，但临床医生通常建议患者在大多数手术前至少1周停止使用非甾体抗炎药（NSAID），包括布洛芬。目的：确定布洛芬诱导的血小板功能障碍的持续时间。设计：前瞻性队列研究。地点：丹佛/奥罗拉，科罗拉多。参与者：11名健康成年志愿者。测量：个体在基线时进行测试，并在完成布洛芬的7天疗程（每8小时口服600 mg）后进行连续测试。血小板功能分析仪（PFA-100，戴德贝林，纽瓦克，特拉华州，一个测试，已取代了出血时间在许多临床settings.Results：所有参与者表现出正常的血小板功能开始布洛芬之前。血小板功能障碍是明显的布洛芬课程完成后，在11名参与者中的7名，并在最后一次布洛芬dose.Limitations后24小时正常化：在这项研究中的样本量很小，没有参与者有重大疾病。PFA-100的结果和临床出血之间的相关性尚未建立。结论：血小板功能似乎正常化后24小时内停止定期使用布洛芬在健康人。进一步的研究是必要的，以提供一个合理的基础，在接受手术的患者范围内的非甾体抗炎药停药的时间。
Background: Despite a paucity of evidence, clinicians routinely advise that patients discontinue using nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, at least 1 week before most surgical procedures.Objective: To define the duration of ibuprofen-induced platelet dysfunction.Design: Prospective cohort study.Setting: Denver/Aurora, Colorado.Participants: 11 healthy adult volunteers.Measurements: individuals were tested at baseline and serially after completion of a 7-day course of ibuprofen (600 mg orally every 8 hours). The platelet function analyzer (PFA-100, Dade Behring, Newark, Delaware, a test that has replaced the bleeding time in many clinical settings, was used.Results: All participants exhibited normal platelet function before starting ibuprofen. Platelet dysfunction was apparent after completion of the ibuprofen course in 7 of the 11 participants and normalized by 24 hours after the last ibuprofen dose.Limitations: The sample size in this study was small, and no participants had a major illness. Correlation between PFA-100 results and clinical bleeding has not been established.Conclusions: Platelet function seems to normalize within 24 hours after cessation of regular ibuprofen use in healthy individuals. Further studies are warranted to provide a rational basis for timing of NSAID withdrawal in a range of patients undergoing surgery.